5-甲氧基-2-三氟甲基苯酚 | 106877-40-1

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 中文名称: 5-甲氧基-2-三氟甲基苯酚
• 英文名称: 5-methoxy-2-(trifluoromethyl)phenol
• CAS: 106877-40-1
• 化学式: C₈H₇F₃O₂
• 分子量: 192.138
• InChiKey: RRHXUHOVPBIAOU-UHFFFAOYSA-N

物化性质

• 沸点：
  229.5±40.0 °C(Predicted)
• 密度：
  1.321±0.06 g/cm3(Predicted)

计算性质

• 辛醇/水分配系数(LogP)：
  2.4
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.25
• 拓扑面积：
  29.5
• 氢给体数：
  1
• 氢受体数：
  5

安全信息

• 海关编码：
  2909500000

反应信息

• 作为反应物：
  描述：

  3-(氨基甲基)吡咯烷-1-羧酸叔丁酯 、 5-甲氧基-2-三氟甲基苯酚 在 caesium carbonate 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 反应 16.0h， 生成
  参考文献：
  名称：

  Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities

  摘要：

  Accumulation of cytotoxic lipofuscin bisretinoids may contribute to atrophic age-related macular degeneration (AMD) pathogenesis. Retinal bisretinoid synthesis depends on the influx of serum all-trans-retinol (1) delivered via a tertiary retinol binding protein 4 (RBP4)-transthyretin (TTR)-retinol complex. We previously identified selective RBP4 antagonists that dissociate circulating RBP4-TTR-retinol complexes, reduce serum RBP4 levels, and inhibit bisretinoid synthesis in models of enhanced retinal lipofuscinogenesis. However, the release of TTR by selective RBP4 antagonists may be associated with TTR tetramer destabilization and, potentially, TTR amyloid formation. We describe herein the identification of bispecific RBP4 antagonist-TTR tetramer kinetic stabilizers. Standout analogue (+/-)-44 possesses suitable potency for both targets, significantly lowers mouse plasma RBP4 levels, and prevents TTR aggregation in a gel-based assay. This new class of bispecific compounds may be especially important as a therapy for dry AMD patients who have another common age-related comorbidity, senile systemic amyloidosis, a nongenetic disease associated with wild-type TTR misfolding.

  DOI：

  10.1021/acs.jmedchem.0c00996
• 作为产物：
  描述：

  3-甲氧基苯酚 、 三氟溴甲烷 在 碳酸甲丙酯 、 sodium metabisulfite 、 二氧化硫 、 锌 作用下， 以 N,N-二甲基甲酰胺 为溶剂， 60.0 ℃ 、500.0 kPa 条件下， 反应 3.0h， 以25%的产率得到3-methoxy-2-trifluoromethylphenol
  参考文献：
  名称：

  Tordeux, Marc; Langlois, Bernard; Wakselman, Claude, Journal of the Chemical Society. Perkin transactions I, 1990, # 8, p. 2293 - 2299

  摘要：

  DOI：

文献信息

• POLYURETHANE, POLYURETHANE PRODUCTION METHOD, CONDUCTIVE PASTE COMPOSITION, CONDUCTIVE WIRE, AND METHOD FOR PRODUCING CONDUCTIVE WIRE
  申请人：SHIN-ETSU CHEMICAL CO., LTD.

  公开号：US20220157484A1

  公开（公告）日：2022-05-19

  A polyurethane contains a weakly acidic functional group having a pKa of 5 to 11. Thus, the present invention provides: a conductive paste composition for forming a stretchable conductive wire which varies slightly in electric conductivity at the time of elongation and shrinkage; and a polyurethane for providing the composition.
• US4731450A
  申请人：——

  公开号：US4731450A

  公开（公告）日：1988-03-15
• Discovery of Bispecific Antagonists of Retinol Binding Protein 4 That Stabilize Transthyretin Tetramers: Scaffolding Hopping, Optimization, and Preclinical Pharmacological Evaluation as a Potential Therapy for Two Common Age-Related Comorbidities
  作者：Christopher L. Cioffi、Parthasarathy Muthuraman、Arun Raja、Andras Varadi、Boglarka Racz、Konstantin Petrukhin

  DOI：10.1021/acs.jmedchem.0c00996

  日期：2020.10.8

  Accumulation of cytotoxic lipofuscin bisretinoids may contribute to atrophic age-related macular degeneration (AMD) pathogenesis. Retinal bisretinoid synthesis depends on the influx of serum all-trans-retinol (1) delivered via a tertiary retinol binding protein 4 (RBP4)-transthyretin (TTR)-retinol complex. We previously identified selective RBP4 antagonists that dissociate circulating RBP4-TTR-retinol complexes, reduce serum RBP4 levels, and inhibit bisretinoid synthesis in models of enhanced retinal lipofuscinogenesis. However, the release of TTR by selective RBP4 antagonists may be associated with TTR tetramer destabilization and, potentially, TTR amyloid formation. We describe herein the identification of bispecific RBP4 antagonist-TTR tetramer kinetic stabilizers. Standout analogue (+/-)-44 possesses suitable potency for both targets, significantly lowers mouse plasma RBP4 levels, and prevents TTR aggregation in a gel-based assay. This new class of bispecific compounds may be especially important as a therapy for dry AMD patients who have another common age-related comorbidity, senile systemic amyloidosis, a nongenetic disease associated with wild-type TTR misfolding.
• Tordeux, Marc; Langlois, Bernard; Wakselman, Claude, Journal of the Chemical Society. Perkin transactions I, 1990, # 8, p. 2293 - 2299
  作者：Tordeux, Marc、Langlois, Bernard、Wakselman, Claude

  DOI：——

  日期：——