(3S,5S)-3-(anilinomethyl)-5-(3,3,3-trifluoropropoxy)hexanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (3S,5S)-3-(anilinomethyl)-5-(3,3,3-trifluoropropoxy)hexanoic acid
• 化学式: C₁₆H₂₂F₃NO₃
• 分子量: 333.35
• InChiKey: YLDXJZHVWIBJEQ-STQMWFEESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.8
• 重原子数：
  23
• 可旋转键数：
  10
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  58.6
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT
  申请人：Aldeyra Therapeutics, Inc.

  公开号：EP2948149A2

  公开（公告）日：2015-12-02
• [EN] TOXIC ALDEHYDE RELATED DISEASES AND TREATMENT<br/>[FR] MALADIES LIÉES À UN ALDÉHYDE TOXIQUE ET TRAITEMENT
  申请人：ALDEXA THERAPEUTICS INC

  公开号：WO2014116836A2

  公开（公告）日：2014-07-31

  The present invention provides for the treatment, prevention, and/or reduction of a risk of a disease, disorder, or condition in which aldehyde toxicity is implicated in the pathogenesis, including ocular disorders, skin disorders, conditions associated with injurious effects from blister agents, and autoimmune, inflammatory, neurological and cardiovascular diseases by the use of a primary amine to scavenge toxic aldehydes, such as MDA and HNE.