(2S)-2-amino-5-(1-(15N)azanylethenylamino)pentanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-5-(1-(15N)azanylethenylamino)pentanoic acid
• 化学式: C7H15N3O2
• 分子量: 174.21
• InChiKey: CQHCZLMAXVFEMU-DWNZYCRPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.3
• 重原子数：
  12
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  101
• 氢给体数：
  4
• 氢受体数：
  5

文献信息

• Addition salts of amines containing hydroxyl and/or carboxylic groups with amino nicotinic acid derivatives as DHODH inhibitors
  申请人：Almirall, S.A.

  公开号：EP2228367A1

  公开（公告）日：2010-09-15

  The present invention is directed to novel water-soluble pharmaceutically acceptable, crystalline addition salts of (i) an amine containing one or more hydroxyl and/or carboxylic groups with (ii) amino nicotinic acid derivatives of formula (I) wherein Ra, Rb, Rc and Rd independently represent groups selected from hydrogen atoms, halogen atoms, C1-4 alkyl groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and C1-4 alkoxy groups which may be optionally substituted by 1, 2 or 3 substituents selected from halogen atoms and hydroxy groups, and pharmaceutically acceptable solvates thereof.

  该发明涉及一种新型水溶性药用可接受的结晶加合盐，该盐包括(i)含有一个或多个羟基和/或羧基的胺与(ii)式(I)的氨基烟酸衍生物之间的结合，其中Ra、Rb、Rc和Rd独立地表示从氢原子、卤原子、可能被1、2或3个卤原子和羟基选择的C1-4烷基组成的基团，以及可能被1、2或3个卤原子和羟基选择的C1-4烷氧基组成的基团，以及其药用可接受的溶剂化合物。
• PROCESS FOR THE PREPARATION OF THE L-ARGININE SALT OF PERINDOPRIL
  申请人：Les Laboratoires Servier

  公开号：US20130178635A1

  公开（公告）日：2013-07-11

  Process for the preparation of the compound of formula (I):

  制备式(I)化合物的过程：
• DELTA CRYSTALLINE FORM OF THE ARGININE SALT OF PERINDOPRIL, A PROCESS FOR ITS PREPARATION, AND PHARMACEUTICAL COMPOSITIONS CONTAINING IT
  申请人：LES LABORATOIRES SERVIER

  公开号：US20130178464A1

  公开（公告）日：2013-07-11

  Delta crystalline form of the compound of formula (I): characterised by its X-ray powder diffraction diagram. Medicinal products containing the same which are useful in the treatment of cardiovascular diseases.

  化合物公式(I)的Delta晶体形式：其特征为其X射线粉末衍射图谱。含有该晶体形式的药物制剂在心血管疾病治疗中有用。
• Chemical mechanical polish slurry and method of manufacture
  申请人：Taiwan Semiconductor Manufacturing Company, Ltd.

  公开号：US11043396B2

  公开（公告）日：2021-06-22

  Methods of manufacturing a chemical-mechanical polishing (CMP) slurry and methods of performing CMP process on a substrate comprising metal features are described herein. The CMP slurry may be manufactured using a balanced concentration ratio of chelator additives to inhibitor additives, the ratio being determined based on an electro potential (Ev) value of a metal material of the substrate. The CMP process may be performed on the substrate based on the balanced concentration ratio of chelator additives to inhibitor additives of the CMP slurry.

  本文描述了制造化学机械抛光（CMP）浆料的方法以及在包含金属特征的基底上执行 CMP 工艺的方法。可以使用螯合剂添加剂与抑制剂添加剂的平衡浓度比来制造 CMP 泥浆，该比例根据基底金属材料的电位 (Ev) 值来确定。可根据 CMP 浆料中螯合剂添加剂与抑制剂添加剂的平衡浓度比在基底上执行 CMP 工艺。
• DERIVATE VON N OMEGA-HYDROXY-L-ARGININ ZUR BEHANDLUNG VON KRANKHEITEN
  申请人：Christian-Albrechts-Universität zu Kiel

  公开号：EP2424515B1

  公开（公告）日：2017-03-22