(5S,6R,7S)-6-hydroxy-3,3,5,7-tetramethyl-8-phenylmethoxy-2-propan-2-yloxyoctan-4-one

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: (5S,6R,7S)-6-hydroxy-3,3,5,7-tetramethyl-8-phenylmethoxy-2-propan-2-yloxyoctan-4-one
• 化学式: C₂₂H₃₆O₄
• 分子量: 364.5
• InChiKey: VZQPDNPYRPWYCB-DCAMYXFASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  26
• 可旋转键数：
  11
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.68
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• SYNTHESIS OF EPOTHILONES, INTERMEDIATES THERETO AND ANALOGUES THEREOF
  申请人：Sloan-Kettering Institute for Cancer Research

  公开号：US20140213618A1

  公开（公告）日：2014-07-31

  The present invention provides compounds of formula (I): as described generally and in classes and subclasses herein. The present invention additionally provides pharmaceutical compositions comprising compounds of formula (I) and provides methods of treating cancer comprising administering a compound of formula (I).