| 1224698-68-3

• 分子结构分类: 有机化合物 - 木脂素、新木脂素和相关化合物 - 木脂素内酯
• CAS: 1224698-68-3
• 化学式: C₄₀H₄₅N₂O₁₂
• 分子量: 745.803
• InChiKey: CISKOQJBEJSQEU-SZPLEQTMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.8
• 重原子数：
  54
• 可旋转键数：
  11
• 环数：
  7.0
• sp3杂化的碳原子比例：
  0.47
• 拓扑面积：
  152
• 氢给体数：
  2
• 氢受体数：
  12

反应信息

• 作为产物：
  描述：

  4 ’-去甲去氧鬼臼毒素 、 在 4-二甲氨基吡啶 、 N,N'-二环己基碳二亚胺 作用下， 以 二氯甲烷 为溶剂， 反应 4.0h， 以44%的产率得到
  参考文献：
  名称：

  First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin

  摘要：

  Deoxypodophyllotoxin inhibits tubulin polymerization and induces cell cycle arrest at G2/M, followed by apoptosis. In order to find compounds with superior bioactivity and less toxicity, a series of spin-labeled derivatives of deoxypodophyllotoxin were synthesized by reacting 4'-demethyl-4-deoxypodophyllotoxin (DPPT) with N-(1-oxy1-2,2,6,6-tetramethyl-4-piperidinyloxycarbonyl) amino acids. The cytotoxic activities against three tumor cell lines (HL-60, RPMI-8226, A-549) in vitro and the antioxidative activities in tissues of Sprague Dawley (SD) rats of target compounds were evaluated, and the results indicated that compounds 11a-h were more potent in terms of cytotoxicities and antioxidative activities than either parent compound DPPT or anticancer drug VP-16. (C) 2009 Elsevier Masson SAS. All rights reserved.

  DOI：

  10.1016/j.ejmech.2009.12.032

文献信息

• First synthesis and biological evaluation of novel spin-labeled derivatives of deoxypodophyllotoxin
  作者：Zhi-Wei Zhang、Jia-Qiang Zhang、Ling Hui、Shi-Wu Chen、Xuan Tian

  DOI：10.1016/j.ejmech.2009.12.032

  日期：2010.4

  Deoxypodophyllotoxin inhibits tubulin polymerization and induces cell cycle arrest at G2/M, followed by apoptosis. In order to find compounds with superior bioactivity and less toxicity, a series of spin-labeled derivatives of deoxypodophyllotoxin were synthesized by reacting 4'-demethyl-4-deoxypodophyllotoxin (DPPT) with N-(1-oxy1-2,2,6,6-tetramethyl-4-piperidinyloxycarbonyl) amino acids. The cytotoxic activities against three tumor cell lines (HL-60, RPMI-8226, A-549) in vitro and the antioxidative activities in tissues of Sprague Dawley (SD) rats of target compounds were evaluated, and the results indicated that compounds 11a-h were more potent in terms of cytotoxicities and antioxidative activities than either parent compound DPPT or anticancer drug VP-16. (C) 2009 Elsevier Masson SAS. All rights reserved.