(5E)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-3-methyl-2-[(E)-2-nitroethenyl]imidazol-4-one

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (5E)-5-[(3,5-difluoro-4-hydroxyphenyl)methylidene]-3-methyl-2-[(E)-2-nitroethenyl]imidazol-4-one
• 化学式: C13H9F2N3O4
• 分子量: 309.22
• InChiKey: PECDHMYMWKATOD-RCFWGOLESA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  22
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.08
• 拓扑面积：
  98.7
• 氢给体数：
  1
• 氢受体数：
  7

文献信息

• Method for RNA detection and quantification
  申请人：Cornell University

  公开号：US10444224B2

  公开（公告）日：2019-10-15

  The present invention relates to novel nucleic acid molecules, called aptamers, that bind specifically to a small molecule fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.

  本发明涉及被称为适配体的新型核酸分子，它们能与小分子荧光团特异性结合，从而在暴露于适当波长的辐射时增强荧光团的荧光信号。本发明描述了新型荧光团、新型核酸分子及其目标分子之间形成的分子复合物，还描述了如何使用多价适配体构建物作为荧光传感器来检测感兴趣的目标分子。
• METHODS FOR RNA DETECTION AND QUANTIFICATION
  申请人：Jaffrey Samie R.

  公开号：US20140220560A1

  公开（公告）日：2014-08-07

  The present invention relates to novel nucleic acid molecules, called aptamers, that bind specifically to a small molecule fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.
• RNA SEQUENCES THAT INDUCE FLUORESCENCE OF SMALL MOLECULE FLUOROPHORES
  申请人：Cornell University

  公开号：US20150141282A1

  公开（公告）日：2015-05-21

  The present invention relates to novel nucleic acid molecules, called aptamers, that bind specifically to a small molecule fluorophore and thereby enhance the fluorescence signal of the fluorophore upon exposure to radiation of suitable wavelength. Molecular complexes formed between the novel fluorophores, novel nucleic acid molecules, and their target molecules are described, and the use of multivalent aptamer constructs as fluorescent sensors for target molecules of interest are also described.
• US9664676B2
  申请人：——

  公开号：US9664676B2

  公开（公告）日：2017-05-30