{(S)-6-[(R)-4-(6,7-dihydro-thiazolo[5,4-c]pyridin-5-ylmethyl)-5-trifluoromethaneyl-dihydroinden-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-ethanoic acid methyl ester | 1621168-75-9

• 分子结构分类: 有机化合物 - 苯类化合物 - 茚满类
• 英文名称: {(S)-6-[(R)-4-(6,7-dihydro-thiazolo[5,4-c]pyridin-5-ylmethyl)-5-trifluoromethaneyl-dihydroinden-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-ethanoic acid methyl ester
• 英文别名: {(S)-6-[(R)-4-(6,7-dihydro-thiazolo[5,4-c]pyridin-5-ylmethyl)-5-trifluoromethyl-dihydroinden-1-yloxy]-2,3-dihydro-benzofuran-3-yl}-ethanoic acid methyl ester；methyl 2-[(3S)-6-[[(1R)-4-(6,7-dihydro-4H-[1,3]thiazolo[5,4-c]pyridin-5-ylmethyl)-5-(trifluoromethyl)-2,3-dihydro-1H-inden-1-yl]oxy]-2,3-dihydro-1-benzofuran-3-yl]acetate
• CAS: 1621168-75-9
• 化学式: C₂₈H₂₇F₃N₂O₄S
• 分子量: 544.595
• InChiKey: QUJBRYCWKGEMKZ-VOIUYBSRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.8
• 重原子数：
  38
• 可旋转键数：
  7
• 环数：
  6.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  89.1
• 氢给体数：
  0
• 氢受体数：
  10

文献信息

• INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS
  申请人：ECKHARDT Matthias

  公开号：US20140221349A1

  公开（公告）日：2014-08-07

  Compounds of general formula I wherein the group R 1 is defined as in claim 1 , which have valuable pharmacological properties, in particular bind to the GPR40 receptor and modulate its activity. The compounds are suitable for treatment and prevention of diseases which can be influenced by this receptor, such as metabolic diseases, in particular diabetes type 2.

  通式I的化合物，其中基团R1如权利要求1所定义，具有有价值的药理学特性，特别是结合GPR40受体并调节其活性。这些化合物适用于治疗和预防可以受到该受体影响的疾病，例如代谢性疾病，特别是2型糖尿病。
• NEW INDANYLOXYDIHYDROBENZOFURANYLACETIC ACIDS
  申请人：Boehringer Ingelheim International GmbH

  公开号：EP2953681B1

  公开（公告）日：2017-03-15
• US8927531B2
  申请人：——

  公开号：US8927531B2

  公开（公告）日：2015-01-06