(2S)-2-[carboxy(methyl)amino]pentanedioic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-[carboxy(methyl)amino]pentanedioic acid
• 化学式: C₇H₁₁NO₆
• 分子量: 205.17
• InChiKey: ONQPILVRTMLUDL-BYPYZUCNSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  14
• 可旋转键数：
  5
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.57
• 拓扑面积：
  115
• 氢给体数：
  3
• 氢受体数：
  6

文献信息

• GENERATION OF CYTOTOXIC TUMOR SPECIFIC CELL LINES AND USES THEREOF
  申请人：Ramot at Tel-Aviv University Ltd.

  公开号：EP2950808A1

  公开（公告）日：2015-12-09
• [EN] GENERATION OF CYTOTOXIC TUMOR SPECIFIC CELL LINES AND USES THEREOF<br/>[FR] GÉNÉRATION DE LIGNÉES CELLULAIRES SPÉCIFIQUES D'UNE TUMEUR CYTOTOXIQUES ET LEURS UTILISATIONS
  申请人：UNIV RAMOT

  公开号：WO2014118785A1

  公开（公告）日：2014-08-07

  An in-vitro method of activating T cells is disclosed. The method comprises incubating T cells with pathogenic cells in the presence of a multimeric peptide comprising at least two peptide monomers linked to one another, each of the at least two peptide monomers comprising at least 6 consecutive amino acids from the amino acid sequence as set forth in SEQ ID NO: 1, wherein the at least two peptide monomers are each no longer than 30 amino acids, wherein the multimeric peptide is capable of reducing binding of PLIF to human leukocytes under conditions which allow expansion of the T cells.