H-D-Glu-Gly-Arg-pNA

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-D-Glu-Gly-Arg-pNA
• 英文别名: (4R)-4-amino-5-[[2-[[(2S)-5-(diaminomethylideneamino)-1-(4-nitroanilino)-1-oxopentan-2-yl]amino]-2-oxoethyl]amino]-5-oxopentanoic acid
• 化学式: C19H28N8O7
• 分子量: 480.5
• InChiKey: CAHPNBROIJUPKS-KGLIPLIRSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -4.5
• 重原子数：
  34
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.42
• 拓扑面积：
  261
• 氢给体数：
  7
• 氢受体数：
  9

文献信息

• [EN] ANTIBODIES SPECIFIC FOR UROKINASE-TYPE PLASMINOGEN ACTIVATOR AND METHODS OF USE THEREOF<br/>[FR] ANTICORPS SPÉCIFIQUES POUR L'ACTIVATEUR DE PLASMINOGÈNE DE TYPE UROKINASE ET PROCÉDÉS D'UTILISATION DE CEUX-CI
  申请人：UNIV CALIFORNIA

  公开号：WO2014120555A1

  公开（公告）日：2014-08-07

  The present disclosure relates to antibodies specific for urokinase-type plasminogen activator (uPA). According to certain embodiments, the anti-uPA antibody specifically binds to the active form of uPA. In certain aspects, the anti-uPA antibody that specifically binds to active uPA binds specifically to the active form of human uPA (e.g., the antibody does not cross-react with active forms of uPA from nonhuman organisms). In certain aspects, an anti-uPA antibody of the present disclosure competes for specific binding to uPA with plasminogen activator inhibitor type 1 (PAI -1 ), where binding of the antibody to uPA results in internalization of a complex that includes the antibody, uPA, and urokinase-type plasminogen activator receptor (uPAR).