(2S)-2-amino-3-phenylpropanoic acid;piperazine-2,3-dione;(2S)-pyrrolidine-2-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-3-phenylpropanoic acid;piperazine-2,3-dione;(2S)-pyrrolidine-2-carboxylic acid
• 化学式: C18H26N4O6
• 分子量: 394.4
• InChiKey: JPIUBCQOKRJTFL-OMSMUOAWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.3
• 重原子数：
  28
• 可旋转键数：
  4
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.44
• 拓扑面积：
  171
• 氢给体数：
  6
• 氢受体数：
  8

文献信息

• METHODS FOR PRODUCING DIKETOPIPERAZINES AND COMPOSITIONS CONTAINING DIKETOPIPERAZINES
  申请人：Ampio Pharmaceuticals, Inc.

  公开号：EP2950811A1

  公开（公告）日：2015-12-09
• [EN] METHODS FOR PRODUCING DIKETOPIPERAZINES AND COMPOSITIONS CONTAINING DIKETOPIPERAZINES<br/>[FR] PROCÉDÉS DE PRODUCTION DE DICÉTOPIPÉRAZINES ET COMPOSITIONS EN CONTENANT
  申请人：AMPIO PHARMACEUTICALS INC

  公开号：WO2014121210A1

  公开（公告）日：2014-08-07

  Methods of making increased amounts of diketopiperazines (DKP) such as DA- DKP in pharmaceutical compositions of proteins and peptides are disclosed. The disclosure further provides methods of making a DKP, including (1) contacting albumin with an enzyme (such as a dipeptidyl peptidase IV (DPP-IV)) that cleaves a pair of N- terminal amino acids from the albumin, and (2 heating the albumin under conditions effective to cause the formation of the DKP. Further, treatment of DKP- and albumin- containing streams to produce improved, higher value, DKP compositions and purified albumin compositions for therapeutic uses is also disclosed. In addition to a first therapeutic DKP composition comprising a low albumin content, a second valuable therapeutic composition is also produced characterized by a high albumin concentration.