[rac]-2-ethoxy-3-(4-hydroxy-3-methoxy-phenyl)-propionic acid ethyl ester | 343870-75-7

• 分子结构分类: 有机化合物 - 苯类化合物 - 酚类
• 英文名称: [rac]-2-ethoxy-3-(4-hydroxy-3-methoxy-phenyl)-propionic acid ethyl ester
• 英文别名: ethyl 2-ethoxy-3-(4-hydroxy-3-methoxyphenyl)propanoate
• CAS: 343870-75-7
• 化学式: C₁₄H₂₀O₅
• 分子量: 268.31
• InChiKey: ZBPGUNCFZKOHJD-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  65
• 氢给体数：
  1
• 氢受体数：
  5

反应信息

• 作为反应物：
  描述：

  [rac]-2-ethoxy-3-(4-hydroxy-3-methoxy-phenyl)-propionic acid ethyl ester 在 potassium carbonate 作用下， 以 N,N-二甲基甲酰胺 、 丙酮 为溶剂， 反应 120.0h， 生成 2-Ethoxy-3-{3-methoxy-4-[2-(6-oxo-5,6-dihydro-4-oxa-1-thia-7-aza-inden-7-yl)-ethoxy]-phenyl}-propionic acid ethyl ester
  参考文献：
  名称：

  Novel thieno oxazine analogues as antihyperglycemic and lipid modulating agents

  摘要：

  A series of phenyl acetic acid and alpha-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00976-9
• 作为产物：
  描述：

  4-苄氧基-3-甲氧基苯甲醛 在 palladium on activated charcoal 氢气 、 sodium hydride 作用下， 以 四氢呋喃 、 1,4-二氧六环 为溶剂， 20.0 ℃ 、413.68 kPa 条件下， 生成 [rac]-2-ethoxy-3-(4-hydroxy-3-methoxy-phenyl)-propionic acid ethyl ester
  参考文献：
  名称：

  Novel thieno oxazine analogues as antihyperglycemic and lipid modulating agents

  摘要：

  A series of phenyl acetic acid and alpha-hydroxy propionic acid derivatives were synthesized. In vivo studies of the compounds indicated compound 2c as the most potent in one of the series, which has both glucose and lipid lowering properties. The syntheses and biological studies have been discussed. (C) 2002 Elsevier Science Ltd. All rights reserved.

  DOI：

  10.1016/s0960-894x(02)00976-9

文献信息

• Oxazole derivatives
  申请人：——

  公开号：US20030055265A1

  公开（公告）日：2003-03-20

  The present invention relates to novel oxazole compounds which act as PPAR&agr; and PPAR&ggr; agonists and are accordingly useful for the treatment of diseases modulated by PPAR&agr; and PPAR&ggr; such as diabetes.

  本发明涉及新型噁唑化合物，其作为PPAR&agr;和PPAR&ggr;激动剂，并因此可用于治疗由PPAR&agr;和PPAR&ggr;调节的疾病，如糖尿病。
• [EN] NOVEL 2-ARYLTHIAZOLE COMPOUNDS AS PPARALPHA AND PPARGAMA AGONISTS<br/>[FR] NOUVEAUX COMPOSES 2-ARYLTHIAZOLE UTILISES COMME AGONISTES DES RECEPTEURS PPARALPHA ET PPARGAMMA
  申请人：HOFFMANN LA ROCHE

  公开号：WO2004020420A1

  公开（公告）日：2004-03-11

  The present invention relates to compounds of formula (I) wherein Rl to R10, X, Y and n are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of diseases such as diabetes.

  本发明涉及式(I)的化合物，其中R1至R10、X、Y和n如描述和权利要求中所定义，并且其药学上可接受的盐和酯。这些化合物对于治疗疾病如糖尿病是有用的。
• Tri-substituted phenyl derivatives and analogues
  申请人：——

  公开号：US20030149104A1

  公开（公告）日：2003-08-07

  The present invention relates to certain tri-substituted phenyl derivatives and analogues of formula (I), to a process for preparing such compounds, having the utility in clinical conditions associated with insulin resistance, to methods for their therapeutic use and to pharmaceutical compositions containing them.

  本发明涉及某些三取代苯基衍生物和公式(I)的类似物，以及制备这些化合物的方法，其在与胰岛素抵抗相关的临床状况中具有用途，以及它们的治疗用途方法和含有它们的药物组合物。
• [EN] CARBOXYLIC ACID SUBSTITUTED OXAZOLE DERIVATIVES FOR USE AS PPAR-ALPHA AND -GAMMA ACTIVATORS IN THE TREATMENT OF DIABETES<br/>[FR] DERIVES D'OXAZOLE SUBSTITUES PAR DE L'ACIDE CARBOXYLIQUE UTILES EN TANT QU'ACTIVATEURS PPAR-ALPHA ET GAMMA DANS LE TRAITEMENT DU DIABETE
  申请人：HOFFMANN LA ROCHE

  公开号：WO2002092084A1

  公开（公告）日：2002-11-21

  The present invention relates to compounds of formula (I) wherein R1 to R7 are as defined in the description and claims, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of diseases such as diabetes.

  本发明涉及式(I)的化合物，其中R1至R7如描述和权利要求中所定义，并且其药学上可接受的盐和酯。该化合物可用于治疗糖尿病等疾病。
• Thiazole derivatives
  申请人：——

  公开号：US20040110807A1

  公开（公告）日：2004-06-10

  The present invention provides compounds of formula (I) 1 wherein R 1 to R 10 , X, Y and n are indicated in the specification, and pharmaceutically acceptable salts and esters thereof. The compounds are useful for the treatment of non-insulin dependent diabetes mellitus.

  本发明提供了式(I)1的化合物，其中R1至R10、X、Y和n在规范中指定，并且其药学上可接受的盐和酯。该化合物可用于治疗非胰岛素依赖型糖尿病。