2-(3-methyl-2,5-dioxopyrrolidin-1-yl)ethylcarbamothioic S-acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-(3-methyl-2,5-dioxopyrrolidin-1-yl)ethylcarbamothioic S-acid
• 化学式: C₈H₁₂N₂O₃S
• 分子量: 216.26
• InChiKey: UJGZUMBQKYMDNX-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.4
• 重原子数：
  14
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  67.5
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• IMMUNE-STIMULATING PHOTOACTIVE HYBRID NANOPARTICLES
  申请人：Dhar Shanta

  公开号：US20140220143A1

  公开（公告）日：2014-08-07

  Provides is a therapeutic technology that combines the phototoxic and immune-stimulating ability of photodynamic therapy with the widespread effectiveness of the immune system to reduce the viability of such as cancer cells and tumors. The nanoparticle compositions of the disclosure combine an immunostimulant with a photosensitizer using a nanoparticle delivery platform. For example, zinc pthalocyanine, which is a long-wavelength absorbing photosensitizer, integrated into a polymeric nanoparticle core made up of poly(D,L-lactic-co-glycolic acid)-b-poly(ethylene glycol) (PLGA-b-PEG). The outside surface of the core can be coated with metallic nanoparticles, which are then modified with CpG-ODN. Metastatic mouse breast carcinoma cells showed significant photocytotoxicity of the hybrid after irradiation with a 660 nm LASER light and this activity was remarkably better than either treatment alone. Treatment of mouse bone marrow derived dendritic cells with the photodynamic therapy-killed 4T1 cell lysate showed that the combination of photodynamic therapy with a synergistic immunostimulant in a single nanoparticle system resulted in an immune response suitable for the treatment of such as a metastatic cancer.
• US9517277B2
  申请人：——

  公开号：US9517277B2

  公开（公告）日：2016-12-13