4-[[1-(2,5-dioxopyrrolidin-1-yl)-5-nitro-2H-pyridin-2-yl]disulfanyl]butanoate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 4-[[1-(2,5-dioxopyrrolidin-1-yl)-5-nitro-2H-pyridin-2-yl]disulfanyl]butanoate
• 化学式: C13H14N3O6S2-
• 分子量: 372.4
• InChiKey: XRCZVLDOCLLUMS-UHFFFAOYSA-M

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  24
• 可旋转键数：
  6
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  177
• 氢给体数：
  0
• 氢受体数：
  9

文献信息

• PROLACTIN RECEPTOR BINDING PROTEINS AND USES THEREOF
  申请人：ABBVIE INC.

  公开号：US20140227294A1

  公开（公告）日：2014-08-14

  The present invention encompasses PRLR binding proteins. Specifically, the invention relates to antibodies that are chimeric, CDR grafted and humanized antibodies. Preferred antibodies have high affinity for hPRLR and neutralize hPRLR activity in vitro and in vivo. An antibody of the invention can be a full-length antibody or an antigen-binding portion thereof. Methods of making and methods of using the antibodies of the invention are also provided. The antibodies, or antibody portions, of the invention are useful for detecting hPRLR and for inhibiting hPRLR activity, e.g., in a human subject suffering from a disorder in which hPRLR activity is detrimental. Also included in the invention are anti-PRLR antibody drug conjugates (ADCs).
• US9725515B2
  申请人：——

  公开号：US9725515B2

  公开（公告）日：2017-08-08