[5-[(4-chlorophenoxy)methyl]oxolan-3-yl]-[[(E)-4-[[[5-[(4-chlorophenoxy)methyl]oxolan-3-yl]-diethylazaniumyl]methoxy]-4-oxobut-2-enoyl]oxymethyl]-diethylazanium

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: [5-[(4-chlorophenoxy)methyl]oxolan-3-yl]-[[(E)-4-[[[5-[(4-chlorophenoxy)methyl]oxolan-3-yl]-diethylazaniumyl]methoxy]-4-oxobut-2-enoyl]oxymethyl]-diethylazanium
• 化学式: C36H50Cl2N2O8+2
• 分子量: 709.7
• InChiKey: UYVAFSKKRFEENW-ISLYRVAYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.8
• 重原子数：
  48
• 可旋转键数：
  20
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.56
• 拓扑面积：
  89.5
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• SIGMA RECEPTORS LIGANDS WITH ANTI-APOPTOTIC AND/OR PRO-APOPTOTIC PROPERTIES, OVER CELLULAR MECHANISMS, EXHIBITING PROTOTYPICAL CYTOPROTECTIVE AND ALSO ANTI-CANCER ACTIVITY
  申请人：Anavex Life Sciences Corp.

  公开号：US20140228375A1

  公开（公告）日：2014-08-14

  The present invention involves new and original sigma receptors ligands: (Mono-or dialkylaminoalkyl)-γ-butyrolactones, their analogues aminotetrahydroturanes, the (1-adamantyl) benzene alkylamines, the N,N Dialkyl α-[(adamantyl-1)benzyloxy-2] alkylamines and the 3-cyclopentyl adamantyl-amines or alkylamines or-alkyl phenylamines, their enantiomers or diastereoisomers, their pharmaceutically acceptable salts and Quinacrine Me-thylene blue, Asteinizole and their relative analogues with pro-apoptotic and/or anti-apoptotic properties over cellular biochemical mechanisms, with prototypical anti-cancer, antimetastatic and antiviral activities associated with antagonism of the neuropatic pain and, at very low doses, with cytoprotective and cytoregenerative activity against the cytodegenerative diseases.
• US7767860B2
  申请人：——

  公开号：US7767860B2

  公开（公告）日：2010-08-03
• US9180106B2
  申请人：——

  公开号：US9180106B2

  公开（公告）日：2015-11-10