2-(p-chlorophenyl)-4-phenylpyrido[2,3-b]indolizine-10-carbonitrile | 1133220-56-0

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡啶及其衍生物
• 英文名称: 2-(p-chlorophenyl)-4-phenylpyrido[2,3-b]indolizine-10-carbonitrile
• 英文别名: 2-(4-Chlorophenyl)-4-phenylpyrido[2,3-b]indolizine-10-carbonitrile；2-(4-chlorophenyl)-4-phenylpyrido[2,3-b]indolizine-10-carbonitrile
• CAS: 1133220-56-0
• 化学式: C₂₄H₁₄ClN₃
• 分子量: 379.848
• InChiKey: DXKUYMZVHUNAJJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  6.5
• 重原子数：
  28
• 可旋转键数：
  2
• 环数：
  5.0
• sp3杂化的碳原子比例：
  0.0
• 拓扑面积：
  41.1
• 氢给体数：
  0
• 氢受体数：
  2

反应信息

• 作为产物：
  描述：

  对氯苯乙酮 、 2-amino-3-benzoylindolizine-1-carbonitrile 在 potassium tert-butylate 作用下， 反应 6.0h， 以33%的产率得到2-(p-chlorophenyl)-4-phenylpyrido[2,3-b]indolizine-10-carbonitrile
  参考文献：
  名称：

  Preparation of New Nitrogen-bridged Heterocycles. 64. A Smooth Formation of 2,4-Diarylpyrido[2,3-b]indolizine-10-carbonitrile Derivatives

  摘要：

  The syntheses of the title compounds from the reactions of 2-amino-3-(arylcarbonyl)indolizine-1-carbonitriles with various acetophenones in the presence of strong base were investigated. When the reactions were carried out between 2-aminoindolizines and 1.2-equimolar amounts of acetophenones, the yields for the target molecules were low or very low. However, when a large excess of acetophenones were used without any solvent or in as small as amount of solvent as possible, their yields were considerably improved. The smooth hydrolysis of the 10-cyano group to the carbamoyl one was also observed.

  DOI：

  10.3987/com-08-s(f)44

文献信息

• Preparation of New Nitrogen-bridged Heterocycles. 64. A Smooth Formation of 2,4-Diarylpyrido[2,3-b]indolizine-10-carbonitrile Derivatives
  作者：Akikazu Kakehi、Hiroyuki Suga、Shuichi Sato

  DOI：10.3987/com-08-s(f)44

  日期：——

  The syntheses of the title compounds from the reactions of 2-amino-3-(arylcarbonyl)indolizine-1-carbonitriles with various acetophenones in the presence of strong base were investigated. When the reactions were carried out between 2-aminoindolizines and 1.2-equimolar amounts of acetophenones, the yields for the target molecules were low or very low. However, when a large excess of acetophenones were used without any solvent or in as small as amount of solvent as possible, their yields were considerably improved. The smooth hydrolysis of the 10-cyano group to the carbamoyl one was also observed.