(2S)-2-amino-4-methylpentanoic acid;dihydrochloride

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-amino-4-methylpentanoic acid;dihydrochloride
• 化学式: C6H15Cl2NO2
• 分子量: 204.09
• InChiKey: SSEXYOAJXGBEPB-XRIGFGBMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.29
• 重原子数：
  11
• 可旋转键数：
  3
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  63.3
• 氢给体数：
  4
• 氢受体数：
  3

文献信息

• Prodrugs of urolithins and uses thereof
  申请人：Amazentis SA

  公开号：US11180468B2

  公开（公告）日：2021-11-23

  The invention provides compounds of formula (I) or salts thereof: wherein: A, B, C, D, W, X, Y and Z are as defined in the specification, and at least one of A, B, C, D, W, X, Y and Z is OR1; each R1 being independently H or C(═O)R2, and at least one R1 group being C(═O)R2; where each R2 is selected from: CHR3NHR4, where R4 is H and R3 is a group selected from CH3, CH2CH(CH3)2, CH(CH3)CH2CH3, CH2Ph, CH2-3-(1H-indole), CH2CH2SCH3, CH2OH, CHOHCH3, CH2SH, CH2SeH and CH2PhpOH, wherein said R3 group can optionally be substituted by one or more groups selected from halogen, cyano, nitro, ORA or C1-C4 alkyl; or R3 and R4 together with the C and N atoms to which they are attached form a 5-membered heteroalkyl ring, wherein said heteroalkyl ring can optionally be substituted by one or more groups selected from halogen, cyano, nitro, ORA or C1-C3 alkyl, wherein RA is C1-C4 alkyl optionally substituted with one or more halogen, cyano or nitro groups. The compounds are effective pro-drugs for urolithins and they enable the ready delivery of urolithins to the site in the digestive tract where they can be absorbed into the body.

  本发明提供了式 (I) 化合物或其盐类： 其中 A、B、C、D、W、X、Y 和 Z 如说明书中所定义，且 A、B、C、D、W、X、Y 和 Z 中至少有一个是 OR1；每个 R1 独立地为 H 或 C(═O)R2，且至少有一个 R1 基团为 C(═O)R2；其中每个 R2 选自： CHR3NHR4，其中 R4 为 H，R3 为选自 CH3、 CH( )2、CH( ) 、 Ph、CH2-3-(1H-吲哚)、 S 、 OH、CHOH 、 SH、 SeH 和 PhpOH 的基团、 其中所述 R3 基团可任选被一个或多个选自卤素、氰基、硝基、ORA 或 C1-C4 烷基的基团取代； 或 R3 和 R4 与它们所连接的 C 原子和 N 原子一起形成一个 5 元杂烷基环，其中所述杂烷基环可任选被一个或多个选自卤素、氰基、硝基、ORA 或 C1-C3 烷基的基团取代、 其中 RA 是被一个或多个卤素、氰基或硝基任选取代的 C1-C4 烷基。 这些化合物是有效的尿石素原药，可将尿石素直接输送到消化道中可被人体吸收的部位。
• [EN] PRODRUGS OF UROLITHINS AND USES THEREOF<br/>[FR] PRODROGUES D'UROLITHINES ET LEURS UTILISATIONS
  申请人：AMAZENTIS SA

  公开号：WO2015097231A9

  公开（公告）日：2015-12-10
• PRODRUGS OF UROLITIHNS AND USES THEREOF
  申请人：Amazentis SA

  公开号：EP3087064B1

  公开（公告）日：2021-09-15
• PRAME PURIFICATION
  申请人：Germay Olivier C

  公开号：US20140234424A1

  公开（公告）日：2014-08-21

  Methods and processes for the purification of PRAME are provided. In particular, methods for reducing the aggregation of PRAME during a diluent exchange from diluent A to diluent B comprising: (i) adding a polyanionic compound to diluent A prior to or contemporaneously with the exchange; and (ii) exchanging protein from diluent A to diluent B are provided. Compositions produced by the method are also provided.
• Prodrugs Of Urolithins And Uses Thereof
  申请人：AMAZENTIS SA

  公开号：US20160332982A1

  公开（公告）日：2016-11-17

  The invention provides compounds of formula (I) or salts thereof: wherein: A, B, C, D, W, X, Y and Z are as defined in the specification, and at least one of A, B, C, D, W, X, Y and Z is OR 1 ; each R 1 being independently H or C(═O)R 2 , and at least one R 1 group being C(═O)R 2 ; where each R 2 is selected from: CHR 3 NHR 4 , where R 4 is H and R 3 is a group selected from CH 3 , CH 2 CH(CH 3 ) 2 , CH(CH 3 )CH 2 CH 3 , CH 2 Ph, CH 2 -3-(1H-indole), CH 2 CH 2 SCH 3 , CH 2 OH, CHOHCH 3 , CH 2 SH, CH 2 SeH and CH 2 PhpOH, wherein said R 3 group can optionally be substituted by one or more groups selected from halogen, cyano, nitro, OR A or C 1 -C 4 alkyl; or R 3 and R 4 together with the C and N atoms to which they are attached form a 5-membered heteroalkyl ring, wherein said heteroalkyl ring can optionally be substituted by one or more groups selected from halogen, cyano, nitro, OR A or C 1 -C 3 alkyl, wherein R A is C 1 -C 4 alkyl optionally substituted with one or more halogen, cyano or nitro groups. The compounds are effective pro-drugs for urolithins and they enable the ready delivery of urolithins to the site in the digestive tract where they can be absorbed into the body.