1,2,4,4a,5,6-Hexahydropyrano[3,4-d][1,3]thiazine-6-carboxylic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 1,2,4,4a,5,6-Hexahydropyrano[3,4-d][1,3]thiazine-6-carboxylic acid
• 英文别名: 1,2,4,4a,5,6-hexahydropyrano[3,4-d][1,3]thiazine-6-carboxylic acid
• 化学式: C₈H₁₁NO₃S
• 分子量: 201.25
• InChiKey: JLRAQENHXXGCJV-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.8
• 重原子数：
  13
• 可旋转键数：
  1
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.62
• 拓扑面积：
  83.9
• 氢给体数：
  2
• 氢受体数：
  5

文献信息

• HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3]THIAZIN-2-AMINE COMPOUNDS
  申请人：Pfizer Inc.

  公开号：EP2956458A1

  公开（公告）日：2015-12-23
• [EN] HETEROARYL-SUBSTITUTED HEXAHYDROPYRANO [3,4-d][1,3] THIAZIN-2-AMINE COMPOUNDS<br/>[FR] COMPOSÉS HEXAHYDROPYRANO [3,4-D][1,3] THIAZIN-2-AMINE SUBSTITUÉS PAR UN HÉTÉROARYLE
  申请人：PFIZER

  公开号：WO2014125394A1

  公开（公告）日：2014-08-21

  The present invention is directed to compounds, tautomers and pharmaceutically acceptable salts of the compounds which are disclosed, wherein the compounds have the structure of Formula I, and the variables R1 and R2 are as defined in the specification. Corresponding pharmaceutical compositions, methods of treatment, methods of synthesis, and intermediates are also disclosed.