6-[2-[(3-Pentyloxiran-2-yl)methyl]cyclopropyl]hexanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 6-[2-[(3-Pentyloxiran-2-yl)methyl]cyclopropyl]hexanoic acid
• 英文别名: 6-[2-[(3-pentyloxiran-2-yl)methyl]cyclopropyl]hexanoic acid
• 化学式: C₁₇H₃₀O₃
• 分子量: 282.4
• InChiKey: SLVXBXITFBULFG-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5
• 重原子数：
  20
• 可旋转键数：
  12
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.94
• 拓扑面积：
  49.8
• 氢给体数：
  1
• 氢受体数：
  3

文献信息

• PKC activators and combinations thereof
  申请人：Cognitive Research Enterprises, Inc.

  公开号：US10821079B2

  公开（公告）日：2020-11-03

  The present disclosure relates to PKC activators and combinations thereof. The disclosure further relates to compositions, kits, uses, and methods thereof.

  本公开涉及PKC激活剂及其组合物。该公开进一步涉及这些组合物的组成、试剂盒、用途和方法。
• [EN] HALOGENATED ESTERS OF CYCLOPROPANATED UNSATURATED FATTY ACIDS FOR USE IN THE TREATMENT OF NEURODEGENERATIVE DISEASES<br/>[FR] ESTERS HALOGÉNÉS D'ACIDES GRAS INSATURÉS CYCLOPROPANÉS POUR UTILISATION DANS LE TRAITEMENT DE MALADIES NEURODÉGÉNÉRATIVES
  申请人：BRNI NEUROSCIENCES INST

  公开号：WO2015058191A1

  公开（公告）日：2015-04-23

  The present disclosure describes novel PKC-ε activators chosen from halogenated esters of unsaturated fatty acids and derivatives thereof, including halogenated esters of both polyunsaturated and monunsaturated fatty acids and derivatives thereof. The disclosure further relates to compositions, kits, and methods for treatment using the halogenated esters.

  本公开描述了从卤代酯类不饱和脂肪酸及其衍生物中选择的新型PKC-ε激活剂，包括多不饱和脂肪酸和单不饱和脂肪酸的卤代酯及其衍生物。该公开还涉及使用这些卤代酯的组合物、试剂盒和治疗方法。
• PKC ACTIVATORS AND COMBINATIONS THEREOF
  申请人：BLANCHETTE ROCKEFELLER NEUROSCIENCES INSTITUTE

  公开号：US20140315990A1

  公开（公告）日：2014-10-23

  The present disclosure relates to PKC activators and combinations thereof. The disclosure further relates to compositions, kits, uses, and methods thereof.

  本公开涉及PKC激活剂及其组合物。本公开进一步涉及其组成物、套件、用途和方法。
• Halogenated esters of cyclopropanated unsaturated fatty acids for use in the treatment of neurodegenerative diseases
  申请人：Cognitive Research Enterprises, Inc.

  公开号：US11273139B2

  公开（公告）日：2022-03-15

  The present disclosure describes novel PKC-ε activators chosen from halogenated esters of unsaturated fatty acids and derivatives thereof, including halogenated esters of both polyunsaturated and monounsaturated fatty acids and derivatives thereof. The disclosure further relates to compositions, kits, and methods for treatment using the halogenated esters.

  本公开描述了选自不饱和脂肪酸卤代酯及其衍生物（包括多不饱和和单不饱和脂肪酸卤代酯及其衍生物）的新型 PKC-ε 激活剂。本公开还涉及使用卤代酯进行治疗的组合物、试剂盒和方法。
• STIMULUS-ELICITED GENOMIC PROFILE MARKERS OF A NEURODEGENERATIVE CONDITION
  申请人：Blanchette Rockefeller Neurosciences Institute

  公开号：US20140235496A1

  公开（公告）日：2014-08-21

  The present disclosure is directed to methods of diagnosing a neurodegenerative condition, such as Alzheimer's disease, comprising contacting a cell sample from a subject with at least one stimulus, such as a protein and/or polysaccharide mixture, a protein kinase C activator, an Aβ oligomer, an agent, and combinations thereof; and detecting the expression of at least one gene in the cell sample. Methods may further comprise comparing the expression of the at least one gene in the cell sample to the expression of the same at least one gene in control cells; and determining whether the subject has the neurodegenerative condition (e.g., Alzheimer's disease), wherein a change in the expression of the at least one gene in the cell sample compared to the expression of the same at least one gene in the control cells indicates the subject has the neurodegenerative condition (e.g., Alzheimer's disease).