Methyl 2-(thietan-3-yl)acetate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: Methyl 2-(thietan-3-yl)acetate
• 英文别名: methyl 2-(thietan-3-yl)acetate
• 化学式: C₆H₁₀O₂S
• 分子量: 146.21
• InChiKey: VFLBFBLWKCXZON-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.7
• 重原子数：
  9
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  51.6
• 氢给体数：
  0
• 氢受体数：
  3

文献信息

• PROCESSES FOR THE PREPARATION OF THIETANAMINE
  申请人：Cassayre Jerome Yves

  公开号：US20140187788A1

  公开（公告）日：2014-07-03

  The present invention provides processes for the preparation of compounds of formula (I) including processes comprising a. reacting a a compound comprising a thietane moiety in which the carbon atom at the 3 position of the thietane moiety is bonded to a nitrogen atom; wherein the nucleophile is selected the group consisting of: N 3 − , a sulfonamide having two hydrogen atoms bound to the nitrogen atom, a diimide having a hydrogen atom bound to the nitrogen atom or an anion thereof, NH 2 OH and NH 3 ; and b. when the nucleophile used in step a. is N 3 − or NH 2 OH, reacting the compound produced in step a. with a suitable reducing agent to give a compound of formula (I); or when the nucleophile used in step a. is a sulfonamide, reacting the compound produced in step a. with a reagent suitable for cleaving the S—N bond of the sulfonamide group to give a compound of formula (I); or when the nucleophile used in step a. is a diimide, reacting the compound produced in step a. with a reagent suitable for cleaving the C—N bond of the amide group to give a compound of formula (I). The invention also relates to intermediates useful for the preparation of compounds of formula (I).

  本发明提供了制备式(I)化合物的方法，包括以下步骤：a.反应含有噻吩环的化合物，其中噻吩环的3位碳原子与氮原子键合;其中亲核试剂选择如下组：N3−，一个含有两个氢原子与氮原子键合的磺酰胺，一个含有氢原子与氮原子键合或其阴离子的二亚甲基，NH2OH和NH3; b.当步骤a中使用的亲核试剂为N3−或NH2OH时，用适当的还原剂反应步骤a中产生的化合物，以得到式(I)化合物;或者当步骤a中使用的亲核试剂为磺酰胺时，用适合裂解磺酰胺基团的试剂反应步骤a中产生的化合物，以得到式(I)化合物;或者当步骤a中使用的亲核试剂为二亚甲基时，用适合裂解酰胺基团的试剂反应步骤a中产生的化合物，以得到式(I)化合物。本发明还涉及用于制备式(I)化合物的中间体。
• PROCESS FOR THE PREPARATION OF THIETANE DERIVATIVES
  申请人：Cassayre Jerome Yves

  公开号：US20140235869A1

  公开（公告）日：2014-08-21

  The present invention relates to processes for the preparation of thietane derivatives of the formula (IA) and thietane derivatives of the formula (IB) wherein R 1 , R 2 , A 1 , A 2 , A 3 , A 4 , B, and n are as defined in the claims. The invention also relates to intermediates useful in the processes, as well as the compounds of formula (IA) and (IB) and their use as pesticides.

  本发明涉及制备式（IA）的噻环烷衍生物和式（IB）的噻环烷衍生物的过程，其中R1、R2、A1、A2、A3、A4、B和n如权利要求所定义。本发明还涉及有用于该过程的中间体，以及式（IA）和（IB）的化合物及其作为杀虫剂的用途。
• US9006456B2
  申请人：——

  公开号：US9006456B2

  公开（公告）日：2015-04-14
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  申请人：——

  公开号：US9204648B2

  公开（公告）日：2015-12-08
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  申请人：——

  公开号：US9682949B2

  公开（公告）日：2017-06-20