[3-chloro-2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl]-trimethylazanium

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: [3-chloro-2,3-bis[[(Z)-octadec-9-enoyl]oxy]propyl]-trimethylazanium
• 化学式: C42H79ClNO4+
• 分子量: 697.5
• InChiKey: OPJGKDJAMCLICD-YEUCEMRASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  15.8
• 重原子数：
  48
• 可旋转键数：
  37
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  52.6
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• PHOSPHOLIPID-DETERGENT CONJUGATES AND USES THEREOF
  申请人：Lebeau Luc

  公开号：US20140243391A1

  公开（公告）日：2014-08-28

  The invention relates to novel compounds, in particular novel O-substituted phospholipids that are useful for the in vitro and in vivo delivery of drugs as well as nucleic acids into cells. The invention also relates to pharmaceutical compositions and supramolecular complexes comprising said compounds and the use of these compounds in therapeutic treatment, in particular in gene therapy.

  本发明涉及新型化合物，特别是新型O取代磷脂，可用于体外和体内将药物以及核酸输送到细胞中。本发明还涉及包含所述化合物的药物组合物和超分子复合物，以及这些化合物在治疗中的使用，特别是在基因治疗中的使用。
• TRIGLYCERIDE OTIC FORMULATIONS AND USES THEREOF
  申请人：OTONOMY, INC.

  公开号：US20210138069A1

  公开（公告）日：2021-05-13

  Disclosed herein are triglyceride based formulations, compositions, and methods for the treatment of otic diseases and conditions. Such triglyceride based formulations and compositions are derived from long-chain triglycerides and allow for the delivery of a variety of therapeutic agents to the outer, middle, and/or inner ear.