N-[6-bis(phosphanyl)phosphanyl-5-(methylamino)-6-oxohexyl]-2-methyl-6-(methylamino)hexanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[6-bis(phosphanyl)phosphanyl-5-(methylamino)-6-oxohexyl]-2-methyl-6-(methylamino)hexanamide
• 化学式: C₁₅H₃₄N₃O₂P₃
• 分子量: 381.37
• InChiKey: SIDJDDFQOKHGEF-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.6
• 重原子数：
  23
• 可旋转键数：
  14
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.87
• 拓扑面积：
  70.2
• 氢给体数：
  3
• 氢受体数：
  4

文献信息

• Enzyme-Degradable Polymer and Application Thereof
  申请人：Dai Lijun

  公开号：US20140243429A1

  公开（公告）日：2014-08-28

  The present invention belongs to the biomedicine field and specifically concerns an enzyme-degradable polymer and the application thereof. To solve the problem of low sensitivity of the existing assay reagents, the present invention provides an enzyme-degradable polymer and the related application of the polymer. The present invention also provides hydrogels, nano-particles, fluorescent dye-labeled enzyme substrates and kits (packages) for detection or activity-analysis of biological enzymes based on the enzyme-degradable polymer. The formula of the enzyme-degradable polymer is P 1 -(aa) N -(AA) n -X X=[formula 1] wherein, (aa) N is a non-enzyme substrate domain, the N aa may be different (no correlation), and N is a non-negative integer; (AA) n is an enzyme substrate domain, the n AA may be different, and n is a non-negative integer; P 1 is a protecting group of α-amino or functional group; P 2 is a protecting group of α-amino; P 3 is —NH 2 , a small molecule compound or a fragment of a polymer.
• Bioanalytical Reagent used in Heterogeneous Phase and Usage Method Thereof
  申请人：Dai Lijun

  公开号：US20150031046A1

  公开（公告）日：2015-01-29

  A bioanalytical reagent used in a heterogeneous phase and a usage method thereof are provided to increase the signal intensity from the bioanalytical reagent. The bioanalytical reagent includes a target detector and a signal generator. The signal generator is represented by the following formula: (p1) y -(a trigger) z -(LS) N -a degradable polymer coupled with a contrast agent in latent state via covalent bonds-p 2 , wherein p1 is a protecting group for the end group of the trigger, LS is a self-immolative linker or spacer, p2 is a protecting group for the end group of the degradable polymer, y is 0 or 1, and Z, N are non-negative integer. The signal generator is in a latent state during wash and separation procedures, until an inducing matter or a condition, which excites the contrast agent from a latent state to an active state, is added or applied into the analysis system after the separation procedure so as to degrade directly the polymer or to stimulate the triggers in sequence before degrading the polymer. As a result, the detection signal is excited or its intensity is remarkably increased. The bioanalytical reagent used in a heterogeneous phase has high sensitivity and good stability. The bioanalytical reagent used in a heterogeneous phase is employed simply and exactly.
• US9200033B2
  申请人：——

  公开号：US9200033B2

  公开（公告）日：2015-12-01