[3-[2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl] 5-[[5-[[5-[[3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl]oxy]-5-oxopentanoyl]amino]-6-[2-(2-hydroxyethoxy)ethylamino]-6-oxohexyl]amino]-5-oxopentanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: [3-[2-[4-(6-Fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl] 5-[[5-[[5-[[3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl]oxy]-5-oxopentanoyl]amino]-6-[2-(2-hydroxyethoxy)ethylamino]-6-oxohexyl]amino]-5-oxopentanoate
• 英文别名: [3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl] 5-[[5-[[5-[[3-[2-[4-(6-fluoro-1,2-benzoxazol-3-yl)piperidin-1-yl]ethyl]-2-methyl-4-oxo-6,7,8,9-tetrahydropyrido[1,2-a]pyrimidin-9-yl]oxy]-5-oxopentanoyl]amino]-6-[2-(2-hydroxyethoxy)ethylamino]-6-oxohexyl]amino]-5-oxopentanoate
• 化学式: C₆₆H₈₅F₂N₁₁O₁₃
• 分子量: 1278.4
• InChiKey: BAJZJSMLQAEMJT-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  92
• 可旋转键数：
  32
• 环数：
  10.0
• sp3杂化的碳原子比例：
  0.59
• 拓扑面积：
  293
• 氢给体数：
  4
• 氢受体数：
  21

文献信息

• Polymeric Hyperbranched Carrier-Linked Prodrugs
  申请人：Hersel Ulrich

  公开号：US20140243254A1

  公开（公告）日：2014-08-28

  The present invention relates to water-soluble carrier-linked prodrugs of formula (I), wherein POL is a polymeric moiety, each Hyp is independently a hyperbranched moiety, each moiety SP is independently a spacer moiety, each L is independently a reversible prodrug linker moiety, m is 0 or 1, each n is independently an integer from 2 to 200 and each x is independently 0 or 1. It further relates to pharmaceutical compositions comprising said water-soluble carrier-linked prodrugs and methods of treatment.