Thiacyclooctyne

• 分子结构分类: 有机化合物 - 有机杂环化合物
• 英文名称: Thiacyclooctyne
• 英文别名: 1λ4-thiacyclooct-8-yne
• 化学式: C₇H₁₂S
• 分子量: 128.24
• InChiKey: WATSHKDEHKFJBJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.3
• 重原子数：
  8
• 可旋转键数：
  0
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  1
• 氢给体数：
  0
• 氢受体数：
  1

文献信息

• CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS
  申请人：ImmunoGen, Inc.

  公开号：EP2961434A2

  公开（公告）日：2016-01-06
• CONJUGATES COMPRISING CELL-BINDING AGENTS AND MAYTANSINOIDS AS CYTOTOXIC AGENTS
  申请人：IMMUNOGEN, INC.

  公开号：US20150359903A1

  公开（公告）日：2015-12-17

  The invention provides linker compounds containing a disulfide group, and maytansin-derived cytotoxic compounds that are useful for forming a CBA-drug conjugates, and conjugates so formed. Such conjugates and/or cytotoxic compounds may be effective for treating a range of diseases, such as cancer, with a relatively high activity at a relatively low, non-toxic dose.
• TARGETED DELIVERY SYSTEM, SYSTEM COMPONENTS, AND METHODS
  申请人：REGENTS OF THE UNIVERSITY OF MINNESOTA

  公开号：US20170232041A1

  公开（公告）日：2017-08-17

  A method for targeted delivery of cargo to a target locus in a subject and components of the system. Generally, the method includes administering to the subject a cell that has an artificial saccharide-derived target presented on the surface of the cell, allowing the cell to localize to a target locus in the subject, then administering to the subject an agent that specifically binds to the artificial target. In some embodiments, the agent can include a therapeutic compound. In some embodiments, the agent can include a detectable label. In some of these embodiments, that method can further include detecting the detectable label.
• US9901647B2
  申请人：——

  公开号：US9901647B2

  公开（公告）日：2018-02-27
• US9999680B2
  申请人：——

  公开号：US9999680B2

  公开（公告）日：2018-06-19