(2S)-2-(methylamino)-6-[[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrole-2-carbonyl]amino]hexanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2S)-2-(methylamino)-6-[[(2R,3R)-3-methyl-3,4-dihydro-2H-pyrrole-2-carbonyl]amino]hexanoic acid
• 化学式: C₁₃H₂₃N₃O₃
• 分子量: 269.34
• InChiKey: ZWYHAQPKUQTNGG-OUAUKWLOSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.3
• 重原子数：
  19
• 可旋转键数：
  8
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.77
• 拓扑面积：
  90.8
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS
  申请人：ImmunoGen, Inc.

  公开号：EP2961435A2

  公开（公告）日：2016-01-06
• US9901647B2
  申请人：——

  公开号：US9901647B2

  公开（公告）日：2018-02-27
• [EN] CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS<br/>[FR] CONJUGUÉS COMPRENANT DES AGENTS DE LIAISON CELLULAIRE (CBA) ET DES AGENTS CYTOTOXIQUES
  申请人：IMMUNOGEN INC

  公开号：WO2014134457A2

  公开（公告）日：2014-09-04

  The invention provides linker compounds and cytotoxic compounds that are useful for forming a CBA-drug conjugate and conjugates so formed. Such conjugates and/or cytotoxic compounds may be effective for treating a range of diseases, such as cancer, with a relatively high activity at a relatively low, non-toxic dose.
• [EN] CONJUGATES COMPRISING CELL-BINDING AGENTS AND CYTOTOXIC AGENTS<br/>[FR] CONJUGUÉS COMPRENANT DES AGENTS DE LIAISON CELLULAIRE ET DES AGENTS CYTOTOXIQUES
  申请人：IMMUNOGEN INC

  公开号：WO2014194030A2

  公开（公告）日：2014-12-04

  The invention provides a branched linker compound with reactive moieties for forming covalent bonds with multiple cytotoxic agents (drugs) and/or a cell-binding agent (CBA); a cytotoxic compound comprising a branched linker moiety with a reactive group for forming a CBA-drug conjugates; a modified cell-binding agent comprising a branched linker moiety with a reactive group for forming a CBA-drug conjugates; and conjugates so formed. Such conjugates and/or cytotoxic compounds may be effective for treating a range of diseases, such as cancer, with a relatively high activity at a relatively low, non-toxic dose.
• [EN] PREVENTATIVE CANCER THERAPY<br/>[FR] THÉRAPIE PRÉVENTIVE CONTRE LE CANCER
  申请人：PRIOBIO LLC

  公开号：WO2018156645A1

  公开（公告）日：2018-08-30

  The present disclosure relates to methods of identifying a panel of peptide autoantigen elements capable of detecting low abundance cancer-associated autoantibodies, methods of determining a signature of circulating cancer-associated autoantibodies in a subject, methods for identifying cancer-associated autoantibodies, methods of inducing protective immunity against a cancer in a subject, methods of identifying one or more peptide epitopes for inducing protective immunity against a cancer in a subject, and methods of monitoring a cancer in a subject.