2-(1,4-Dioxaspiro[4.5]decan-8-ylidene)butanoic acid

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: 2-(1,4-Dioxaspiro[4.5]decan-8-ylidene)butanoic acid
• 英文别名: 2-(1,4-dioxaspiro[4.5]decan-8-ylidene)butanoic acid
• 化学式: C₁₂H₁₈O₄
• 分子量: 226.27
• InChiKey: VNMVQZKMRJNCGP-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.1
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  55.8
• 氢给体数：
  1
• 氢受体数：
  4

文献信息

• NOVEL COMPOUNDS AS DUAL INHIBITORS OF PHOSPHODIESTERASES AND HISTONE DEACETYLASES
  申请人：Fundacion para la Investigacion Medica Aplicada

  公开号：EP2961741A1

  公开（公告）日：2016-01-06
• SUBSTITUTED AZASPIRO(4.5)DECANE DERIVATIVES
  申请人：Grünenthal GmbH

  公开号：EP3169666B1

  公开（公告）日：2018-06-06
• Substituted Azaspiro(4.5)Decane Derivatives
  申请人：Gruenenthal GmbH

  公开号：US20170210734A1

  公开（公告）日：2017-07-27

  The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and/or the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.
• [EN] NOVEL COMPOUNDS AS DUAL INHIBITORS OF PHOSPHODIESTERASES AND HISTONE DEACETYLASES<br/>[FR] NOUVEAUX COMPOSÉS COMME INHIBITEURS DOUBLE DE PHOSPHODIESTÉRASES ET D'HISTONES DÉACÉTYLASES
  申请人：FUNDACIÓN PARA LA INVESTIGACIÓN MÉDICA APLIC

  公开号：WO2014131855A1

  公开（公告）日：2014-09-04

  It relates to certain compounds having a polycyclic structure and a hydroxamic acid moiety, wherein the polycyclic structure comprises at least three ring systems, wherein one ring system is a polycyclic ring system comprising from 2 to 4 rings; at least one ring is an aromatic ring; and wherein the structure comprises at least 3 nitrogen atoms and 1 oxygen atom. It also relates to a process for their preparation, as well as to pharmaceutical compositions containing them, and to their use in medicine, in particular in the treatment and/or prevention of neurological disorders coursing with a cognition deficit or impairment, or neurodegenerative diseases. wherein B1 is a radical selected from the group consisting of formula (A"), formula (B"), formula (C"), and formula (D"):
• [EN] SUBSTITUTED AZASPIRO(4.5)DECANE DERIVATIVES<br/>[FR] DÉRIVÉS D'AZASPIRO(4,5)DÉCANE SUBSTITUÉS
  申请人：GRUENENTHAL GMBH

  公开号：WO2016008582A1

  公开（公告）日：2016-01-21

  The invention relates to substituted spirocyclic cyclohexane derivatives which have an affinity for the μ opioid receptor and/or the ORL1 receptor, processes for the preparation thereof, medicaments containing these compounds and the use of these compounds for the preparation of medicaments.