2-(5-Chloro-2-ethoxy-4-fluoro-3-methylphenyl)-2-methyl-1,3-dioxolane

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(5-Chloro-2-ethoxy-4-fluoro-3-methylphenyl)-2-methyl-1,3-dioxolane
• 英文别名: 2-(5-chloro-2-ethoxy-4-fluoro-3-methylphenyl)-2-methyl-1,3-dioxolane
• 化学式: C₁₃H₁₆ClFO₃
• 分子量: 274.71
• InChiKey: GOLVHLXPSGERNN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3
• 重原子数：
  18
• 可旋转键数：
  3
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.54
• 拓扑面积：
  27.7
• 氢给体数：
  0
• 氢受体数：
  4

文献信息

• USE OF PYRAZOLOPYRIMIDINE DERIVATIVES FOR THE TREATMENT OF PI3K-DELTA RELATED DISORDERS
  申请人：Incyte Corporation

  公开号：US20140249132A1

  公开（公告）日：2014-09-04

  The present application provides methods of treating PI3Kδ related disorders using compounds of Formula I: or pharmaceutically acceptable salts thereof.

  本申请提供了使用以下化合物治疗PI3Kδ相关疾病的方法： 或其药用盐的方法。
• HETEROCYCLYLAMINES AS PI3K INHIBITORS
  申请人：Incyte Corporation

  公开号：US20160024117A1

  公开（公告）日：2016-01-28

  The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

  本发明提供了式I的杂环胺衍生物：其中变量在此定义，可调节磷脂酰肌醇3-激酶（PI3Ks）的活性，并在治疗与PI3Ks活性相关的疾病，包括炎症性疾病、免疫性疾病、癌症和其他疾病中有用。
• SALTS AND PROCESSES OF PREPARING A PI3K INHIBITOR
  申请人：Incyte Corporation

  公开号：US20160257689A1

  公开（公告）日：2016-09-08

  The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.

  本申请提供了制备(R)-4-(3-((S)-1-(4-氨基-3-甲基-1H-吡唑并[3,4-d]嘧啶-1-基)乙基)-5-氯-2-乙氧基-6-氟苯基)吡咯烷-2-酮的工艺，该工艺可用作磷脂酰肌醇3-激酶-δ（PI3Kδ）的抑制剂，以及与之相关的盐形式和中间体。
• PROCESSES FOR THE PREPARATION OF A PI3K INHIBITOR
  申请人：Incyte Corporation

  公开号：EP3831833A1

  公开（公告）日：2021-06-09

  The present application provides processes for preparing (R)-4-(3-((S)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrimidin-1-yl)ethyl)-5-chloro-2-ethoxy-6-fluorophenyl)pyrrolidin-2-one, which is useful as an inhibitor phosphoinositide 3-kinase-delta (PI3Kδ), as well as a salt form and intermediates related thereto.

  本申请提供了制备(R)-4-(3-((S)-1-(4-氨基-3-甲基-1H-吡唑并[3,4-d]嘧啶-1-基)乙基)-5-氯-2-乙氧基-6-氟苯基)吡咯烷-2-酮的工艺，该工艺可用作磷酸肌酸 3-激酶-δ（PI3Kδ）抑制剂，还提供了盐形式及其相关中间体。
• Heterocyclylamines as PI3K inhibitors
  申请人：Incyte Corporation

  公开号：US10376513B2

  公开（公告）日：2019-08-13

  The present invention provides heterocyclylamine derivatives of Formula I: wherein the variables are defined herein, that modulate the activity of phosphoinositide 3-kinases (PI3Ks) and are useful in the treatment of diseases related to the activity of PI3Ks including, for example, inflammatory disorders, immune-based disorders, cancer, and other diseases.

  本发明提供了式 I 的杂环胺衍生物： 的杂环胺衍生物，其调节磷酸肌醇 3- 激酶 (PI3K) 的活性，可用于治疗与 PI3K 活性有关的疾病，例如炎症性疾病、免疫性疾病、癌症和其它疾病。