tBu-DL-Lys(tBu)-DL-Lys(1)-tBu.tBu-DL-Lys(tBu)-(1)

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: tBu-DL-Lys(tBu)-DL-Lys(1)-tBu.tBu-DL-Lys(tBu)-(1)
• 英文别名: N-[5-[2,6-bis(tert-butylamino)hexanoylamino]-7,7-dimethyl-6-oxooctyl]-2,6-bis(tert-butylamino)hexanamide
• 化学式: C₃₈H₇₈N₆O₃
• 分子量: 667.1
• InChiKey: HKQXMCXIOSSEEL-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  47
• 可旋转键数：
  26
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.92
• 拓扑面积：
  123
• 氢给体数：
  6
• 氢受体数：
  7

文献信息

• Carrier-Linked Prostanoid Prodrugs
  申请人：ASCENDIS PHARMA A/S

  公开号：US20150306239A1

  公开（公告）日：2015-10-29

  The present invention relates to carrier-linked prostanoid prodrugs of formula (I) Z 1 —(X 0 -L 0 -PG 0 ) y (I), wherein Z 1 , X 0 , L 0 , PG 0 and y have the meaning as indicated in the description and claims; pharmaceutically acceptable salts thereof and pharmaceutical compositions comprising the same. It further relates to their use as medicaments, especially for treating, controlling, delaying or preventing pulmonary arterial hypertension.

  本发明涉及公式（I）Z1—（X0-L0-PG0）y（I）的载体-连结前列腺素类似物前药，其中Z1、X0、L0、PG0和y的含义如说明书和权利要求所示；其药物学上可接受的盐和含有它们的制药组合物。它进一步涉及它们作为药物的用途，特别是用于治疗、控制、延迟或预防肺动脉高压。
• Carrier-Linked Prodrugs Having Reversible Carboxylic Ester Linkages
  申请人：Vetter Dirk

  公开号：US20140249093A1

  公开（公告）日：2014-09-04

  The invention provides a carrier-linked prodrugs, wherein the biologically active moieties comprise at least one carboxylic acid and wherein the linkage between the drug moiety and linker is in the form of an ester wherein the hydroxyl group required for ester formation is provided by the linker moiety and the carboxyl group required for ester formation is provided by the drug moiety. The hydroxyl group of the linker is sterically hindered by the presence of an alkyl or aryl group on the carbon directly bound to or adjacent to the carbon carrying the hydroxyl group (α-carbon). The steric effect of the alkyl or aryl group enables greater control of the rate of hydrolytic degradation of such carrier-linked prodrugs.
• Carrier-Linked Treprostinil Prodrugs
  申请人：Hersel Ulrich

  公开号：US20140296150A1

  公开（公告）日：2014-10-02

  The present invention relates to prodrugs or a pharmaceutically acceptable salt thereof comprising a covalent treprostinil carrier conjugate as well as pharmaceutical composition comprising said compounds. The compounds may be used as medicaments, especially for diseases or disorders which can be treated by treprostinil, such as pulmonary arterial hypertension (PAH).
• Sustained Release Composition of Prostacyclin
  申请人：Sprogøe Kennett

  公开号：US20140303245A1

  公开（公告）日：2014-10-09

  The present invention relates to sustained release compositions of prostacyclin, as well as uses thereof, in particular for the prevention and/or treatment of pulmonary arterial hypertension.
• US9561287B2
  申请人：——

  公开号：US9561287B2

  公开（公告）日：2017-02-07