3-[(2R)-2-amino-4,4-dimethyl-3-oxopentyl]sulfanyl-1-methylpyrrolidine-2,5-dione

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[(2R)-2-amino-4,4-dimethyl-3-oxopentyl]sulfanyl-1-methylpyrrolidine-2,5-dione
• 化学式: C₁₂H₂₀N₂O₃S
• 分子量: 272.37
• InChiKey: FAFJHUBJMYTPOJ-JAMMHHFISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.2
• 重原子数：
  18
• 可旋转键数：
  5
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.75
• 拓扑面积：
  106
• 氢给体数：
  1
• 氢受体数：
  5

文献信息

• AMYLIN-CALCITONIN CHIMERIC PEPTIDES CONJUGATED TO DURATION ENHANCING MOIETIES
  申请人：AMYLIN PHARMACEUTICALS, LLC

  公开号：US20140249076A1

  公开（公告）日：2014-09-04

  Provided herein are amylin-calcitonin peptide conjugates having enhanced duration of biological activity, and methods of use thereof. The amylin-calcitonin peptide conjugates include duration enhancing moieties, such as water soluble polymers and long chain aliphatic groups, bound to the amylin-calcitonin peptide. Methods of use are provided for treatment of an eating disorder, insulin resistance, obesity, overweight, abnormal postprandial hyperglycemia, Type I diabetes, Type II diabetes, gestational diabetes, metabolic syndrome, dumping syndrome, hypertension, dyslipidemia, cardiovascular disease, hyperlipidemia, sleep apnea, cancer, pulmonary hypertension, cholescystitis or osteoarthritis.