N-[(2R,4S)-5-hydrazinyl-4-methyl-5-oxo-1-phenylpentan-2-yl]-2-(4-methylpentyl)-1,3-thiazole-4-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[(2R,4S)-5-hydrazinyl-4-methyl-5-oxo-1-phenylpentan-2-yl]-2-(4-methylpentyl)-1,3-thiazole-4-carboxamide
• 化学式: C₂₂H₃₂N₄O₂S
• 分子量: 416.6
• InChiKey: DDUFLGUVMIQEGJ-FUHWJXTLSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4.5
• 重原子数：
  29
• 可旋转键数：
  11
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  125
• 氢给体数：
  3
• 氢受体数：
  5

文献信息

• [EN] PROCESSES FOR PREPARING TUBULYSINS<br/>[FR] PROCÉDÉS DE PRÉPARATION DE TUBULYSINES
  申请人：ENDOCYTE INC

  公开号：WO2014134543A1

  公开（公告）日：2014-09-04

  The invention described herein pertains to processes for preparing tubulysins and derivatives thereof. The invention described herein also pertains to processes for preparing tubulysin conjugates. The invention described herein also pertains to processes for preparing intermediates for preparing tubulysin conjugates. In one step, the alpha-thiazolyl alcohol is protected with triethylsilyl chloride in the presence of imidazole in an aprotic solvent.