3-(methylamino)-4-oxo-N-(2-oxopropyl)pentanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-(methylamino)-4-oxo-N-(2-oxopropyl)pentanamide
• 化学式: C₉H₁₆N₂O₃
• 分子量: 200.23
• InChiKey: MZSZFCNQGXHBJK-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.4
• 重原子数：
  14
• 可旋转键数：
  6
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.67
• 拓扑面积：
  75.3
• 氢给体数：
  2
• 氢受体数：
  4

文献信息

• [EN] FORMULATIONS OF GROWTH HORMONE RELEASING FACTOR (GRF) MOLECULES WITH IMPROVED STABILITY<br/>[FR] FORMULATIONS DE MOLÉCULES DE FACTEUR DE LIBÉRATION D'HORMONE DE CROISSANCE (GRF) AYANT UNE STABILITÉ AMÉLIORÉE
  申请人：THERATECHNOLOGIES INC

  公开号：WO2014131122A1

  公开（公告）日：2014-09-04

  Stabilized solid and liquid pharmaceutical formulations comprising a GRF molecule as active ingredient, such as GRF analogs including those comprising an N-terminal-attached hydrophobic moiety, such as [trans-3-hexenoyl]hGHRH (1-44) amide, are disclosed. The formulation comprises a GRF molecule or a pharmaceutically acceptable salt thereof and a β- cyclodextrin which is not conjugated to the GRF molecule or salt thereof. Also disclosed is the use of the formulation for the treatment of various conditions, methods of preparing the formulation, as well as kits containing it. Methods of stabilizing (e.g., with respect to chemical stability) such GRF molecules, as well as methods of inhibiting their deamidation at Asn8, are also disclosed.