6-(4-chlorophenyl)-2-[(4-methylpiperazin-1-yl)methyl]-4,5-dihydropyridazin-3(2H)-one | 1229037-49-3

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 二嗪类
• 英文名称: 6-(4-chlorophenyl)-2-[(4-methylpiperazin-1-yl)methyl]-4,5-dihydropyridazin-3(2H)-one
• 英文别名: 6-(4-Chlorophenyl)-2-[(4-methylpiperazin-1-yl)methyl]-4,5-dihydropyridazin-3-one
• CAS: 1229037-49-3
• 化学式: C₁₆H₂₁ClN₄O
• 分子量: 320.822
• InChiKey: IWYKMDUPIZGXOY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.7
• 重原子数：
  22
• 可旋转键数：
  3
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.5
• 拓扑面积：
  39.2
• 氢给体数：
  0
• 氢受体数：
  4

反应信息

• 作为产物：
  描述：

  N-甲基哌嗪 、 聚合甲醛 、 2,3,4,5-四氢-6(4-氯苯基)-3(2H-)-吡嗪酮 以 乙醇 为溶剂， 反应 24.0h， 以66%的产率得到6-(4-chlorophenyl)-2-[(4-methylpiperazin-1-yl)methyl]-4,5-dihydropyridazin-3(2H)-one
  参考文献：
  名称：

  Synthesis, characterization and antihypertensive activity of pyridazinone derivatives

  摘要：

  Some 6-(substituted-phenyl)-2-(substitutedmethyl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by reacting 6-substituted-phenyl-4,5-dihydropyridazin-3(2H)-one with cyclic secondary amine under Mannich reaction conditions. The final compounds (15-70) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 16, 19, 24, 30, 39, 42 and 45 showed good antihypertensive activity.

  DOI：

  10.1016/j.ejmech.2010.02.003

文献信息

• Synthesis, characterization and antihypertensive activity of pyridazinone derivatives
  作者：Anees A. Siddiqui、Ravinesh Mishra、Mohammad Shaharyar

  DOI：10.1016/j.ejmech.2010.02.003

  日期：2010.6

  Some 6-(substituted-phenyl)-2-(substitutedmethyl)-4,5-dihydropyridazin-3(2H)-one derivatives were synthesized by reacting 6-substituted-phenyl-4,5-dihydropyridazin-3(2H)-one with cyclic secondary amine under Mannich reaction conditions. The final compounds (15-70) were evaluated for antihypertensive activities by non-invasive method using Tail Cuff method. The compounds 16, 19, 24, 30, 39, 42 and 45 showed good antihypertensive activity.