4-(3,3-Dimethylbutyl)morpholin-3-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 恶嗪烷类
• 英文名称: 4-(3,3-Dimethylbutyl)morpholin-3-one
• 英文别名: 4-(3,3-dimethylbutyl)morpholin-3-one
• 化学式: C₁₀H₁₉NO₂
• 分子量: 185.26
• InChiKey: KVSJDRXJIJJXIJ-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.5
• 重原子数：
  13
• 可旋转键数：
  3
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.9
• 拓扑面积：
  29.5
• 氢给体数：
  0
• 氢受体数：
  2

文献信息

• TREPROSTINIL DERIVATIVE COMPOUNDS AND METHODS OF USING SAME
  申请人：Corsair Pharma, Inc.

  公开号：US20150166503A1

  公开（公告）日：2015-06-18

  Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

  式子 I、II、III 和 IV 所代表的化合物包括替前列环素和前列环素类似物的前药。用途包括治疗肺高压（PH）或肺动脉高压（PAH）。这些化合物的结构可以根据适当的治疗剂量适应特定的应用。可以使用经皮应用。
• Treprostinil derivative compounds and methods of using same
  申请人：CORSAIR PHARMA, INC.

  公开号：US10344012B2

  公开（公告）日：2019-07-09

  Compounds represented by formulae I, II, III, and IV including pro-drugs for treprostinil and prostacyclin analogs. Uses include treatment of pulmonary hypertension (PH) or pulmonary arterial hypertension (PAH). The structures of the compounds can be adapted to the particular application for a suitable treatment dosage. Transdermal applications can be used.

  式 I、II、III 和 IV 所代表的化合物，包括曲普瑞替尼原药和前列环素类似物。用途包括治疗肺动脉高压（PH）或肺动脉高压（PAH）。化合物的结构可根据特定应用进行调整，以获得合适的治疗剂量。可采用透皮应用。
• US20140256730A1
  申请人：——

  公开号：US20140256730A1

  公开（公告）日：2014-09-11
• SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS AS NADPH OXIDASE INHIBITORS
  申请人：Glenmark Pharmaceuticals S.A.

  公开号：US20200247800A1

  公开（公告）日：2020-08-06

  The present application relates to substituted fused heteroaryl and hetero-cyclic compounds, useful as nicotinamide adenine dinucleotide phosphate oxidase inhibitors (NADPH oxidase inhibitors), processes for their preparation, pharmaceutical compositions comprising the compounds, and the use of the compounds or the compositions in the treatment or prevention of various diseases, conditions and/or disorders mediated by NADPH oxidase. (Formula I)
• US9371264B2
  申请人：——

  公开号：US9371264B2

  公开（公告）日：2016-06-21