N-propionyl-5-chlorosalicylhydrazide | 946128-01-4

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯和取代衍生物
• 英文名称: N-propionyl-5-chlorosalicylhydrazide
• 英文别名: H3pcshz；5-chloro-2-hydroxy-N'-propanoylbenzohydrazide
• CAS: 946128-01-4
• 化学式: C₁₀H₁₁ClN₂O₃
• 分子量: 242.662
• InChiKey: ZJUIEZZMLDHWRB-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  16
• 可旋转键数：
  2
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.2
• 拓扑面积：
  78.4
• 氢给体数：
  3
• 氢受体数：
  3

反应信息

• 作为反应物：
  描述：

  甲醇 、 N-propionyl-5-chlorosalicylhydrazide 、 manganese (II) acetate tetrahydrate 在 air 作用下， 以 甲醇 、 N,N-二甲基甲酰胺 为溶剂， 以85.2%的产率得到
  参考文献：
  名称：

  Synthesis, characterization and bioactivity of a novel 18-metallacrown-6: [Mn(pcshz)(CH3OH)]6·4CH3OH·4H2O

  摘要：

  The reaction of N-propionyl-5-chlorosalicylhydrazide (H(3)pcshz) with Mn(OAc)(2)center dot 4H(2)O in methanol solution gives a novel 18-metallacrown-6 [Mn(pcshz)(CH3OH)](6) center dot 4CH(3)OH center dot 4H(2)O (1). The structure of 1 has been determined by X-ray diffraction and it crystallizes in the monoclinic system and space group P2(1)/n. The ring of the metallacrown is consisted of six interlink [Mn-N-N] repeated units through hydrazide N-N group bridging the ring manganese ions. And the ligand enforces the metal ions to form the stereochemistry as a propeller configuration wish alternation Lambda/Delta form. The largest diameters of the disc-shaped hexanuclear ring are about 8.82 angstrom at entrance. 9.83 angstrom at the central of the cavity, respectively. The solution integrity and stability of the metallacrown was studied by electrospray ionization (ESI)-MS and UV-Vis spectroscopy. The results show it is soluble and stable in methanol. Antibacterial screening data indicate the forming of the complex weakens dramatically the antibacterial activity of the ligand H(3)peshz except for Eschericha coli. (C) 2007 Elsevier B.V. All rights reserved.

  DOI：

  10.1016/j.ica.2007.04.002

文献信息

• Synthesis, characterization and bioactivity of a novel 18-metallacrown-6: [Mn(pcshz)(CH3OH)]6·4CH3OH·4H2O
  作者：Feng-Ping Xiao、Long-Fei Jin、Wei Luo、Gong-Zhen Cheng、Zheng-Ping Ji

  DOI：10.1016/j.ica.2007.04.002

  日期：2007.7

  The reaction of N-propionyl-5-chlorosalicylhydrazide (H(3)pcshz) with Mn(OAc)(2)center dot 4H(2)O in methanol solution gives a novel 18-metallacrown-6 [Mn(pcshz)(CH3OH)](6) center dot 4CH(3)OH center dot 4H(2)O (1). The structure of 1 has been determined by X-ray diffraction and it crystallizes in the monoclinic system and space group P2(1)/n. The ring of the metallacrown is consisted of six interlink [Mn-N-N] repeated units through hydrazide N-N group bridging the ring manganese ions. And the ligand enforces the metal ions to form the stereochemistry as a propeller configuration wish alternation Lambda/Delta form. The largest diameters of the disc-shaped hexanuclear ring are about 8.82 angstrom at entrance. 9.83 angstrom at the central of the cavity, respectively. The solution integrity and stability of the metallacrown was studied by electrospray ionization (ESI)-MS and UV-Vis spectroscopy. The results show it is soluble and stable in methanol. Antibacterial screening data indicate the forming of the complex weakens dramatically the antibacterial activity of the ligand H(3)peshz except for Eschericha coli. (C) 2007 Elsevier B.V. All rights reserved.