For-Leu-Phe-(1).Ac-Cys(1)-NH2

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: For-Leu-Phe-(1).Ac-Cys(1)-NH2
• 英文别名: S-[(2R)-2-acetamido-3-amino-3-oxopropyl] (2S)-2-[[(2S)-2-formamido-4-methylpentanoyl]amino]-3-phenylpropanethioate
• 化学式: C₂₁H₃₀N₄O₅S
• 分子量: 450.6
• InChiKey: FRUCGFHWOUSSSH-BZSNNMDCSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.4
• 重原子数：
  31
• 可旋转键数：
  13
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.48
• 拓扑面积：
  173
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• US20140256615A1
  申请人：——

  公开号：US20140256615A1

  公开（公告）日：2014-09-11
• PEPTIDE-BASED QUORUM SENSING INHIBITORS FOR THE ATTENUATION OF VIRULENCE IN STAPHYLOCOCCUS AUREUS
  申请人：WISCONSIN ALUMNI RESEARCH FOUNDATION

  公开号：US20160194360A1

  公开（公告）日：2016-07-07

  Compounds that affect quorum sensing (QS) in Staphylococcus aureus and related Staphylococcus species (e.g., S. epidermidis ). Compounds which modulate one or more of the four AgrC receptors of Staphylococcus species, particularly of Staphylococcus aureus . Modulation includes inhibition or activation of one or more of these four AgrC receptors. These compounds are useful for bacterial interference and are useful for treating bacterial infections, particularly staphylococcal infection. Treatment can include combination of one or more of the compounds of the invention in combination with one or more antibiotics.
• US9227996B2
  申请人：——

  公开号：US9227996B2

  公开（公告）日：2016-01-05