5-amino-2-[[5-amino-2-[(2-amino-3-sulfanylpropanoyl)amino]pentanoyl]amino]-N-[(2R)-5-aminopentan-2-yl]pentanamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 5-amino-2-[[5-amino-2-[(2-amino-3-sulfanylpropanoyl)amino]pentanoyl]amino]-N-[(2R)-5-aminopentan-2-yl]pentanamide
• 化学式: C₁₈H₃₉N₇O₃S
• 分子量: 433.6
• InChiKey: BWYCYTSGTHJCON-AUXXQLBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -2.5
• 重原子数：
  29
• 可旋转键数：
  16
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  192
• 氢给体数：
  8
• 氢受体数：
  8

文献信息

• [EN] MODIFIED POLY(BETA-AMINO ESTER)S FOR DRUG DELIVERY<br/>[FR] POLY(BÊTA-AMINO-ESTERS) MODIFIÉS POUR L'ADMINISTRATION D'UN MÉDICAMENT
  申请人：INST QUÍMIC DE SARRI CETS FUNDACIÓ PRIVADA

  公开号：WO2014136100A1

  公开（公告）日：2014-09-12

  Disclosed are polymers that are poly(beta-amino ester)s (PBAEs) modified with at least one oligopeptide. The polymers may be used in any field where polymers have been found useful including in medical fields, particularly in drug delivery. The polymers are particularly useful in delivering a polynucleotide such as DNA, RNA and siRNA, a small molecule or a protein. Also disclosed are compositions comprising said polymers and an active agent, methods of encapsulating an agent in a matrix of said polymers, and said polymers and compositions for use in medicine.