L-Methionine L-Phenylalanine | 102417-66-3

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: L-Methionine L-Phenylalanine
• 英文别名: methionine-phenylalanine；(2S)-2-amino-4-methylsulfanylbutanoic acid;(2S)-2-amino-3-phenylpropanoic acid
• CAS: 102417-66-3；114570-44-4
• 化学式: C₅H₁₁NO₂S*C₉H₁₁NO₂
• 分子量: 314.406
• InChiKey: GQYAUZAWKROOLF-IPIKRLCPSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0.79
• 重原子数：
  21
• 可旋转键数：
  7
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.43
• 拓扑面积：
  152
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• Compounds which inhibit beta-secretase activity and methods of use thereof
  申请人：Oklahoma Medical Research Foundation

  公开号：US20040121947A1

  公开（公告）日：2004-06-24

  Compounds inhibit memapsin 2 &bgr;-secretase activity and selectively inhibit memapsin 2 &bgr;-secretase activity relative to memapsin 1 &bgr;-secretase activity. The compounds are employed in methods to inhibit memapsin 2 &bgr;-secretase activity, in the treatment of Alzheimer's disease, in the inhibition of hydrolysis of a &bgr;-secretase site of a &bgr;amyloid precursor protein and to decrease &bgr;-amyloid protein in in vitro samples and in mammals. Proteins of memapsin 2 associated with compounds of the invention are crystallized.

  这些化合物抑制memapsin 2 β-分泌酶活性，并相对选择性地抑制memapsin 2 β-分泌酶活性，而相对于memapsin 1 β-分泌酶活性。这些化合物用于抑制memapsin 2 β-分泌酶活性的方法，用于治疗阿尔茨海默病，用于抑制β淀粉样前体蛋白的β-分泌酶位点的水解，并用于减少体外样本和哺乳动物中的β-淀粉样蛋白。与本发明的化合物相关的memapsin 2蛋白被结晶。
• [EN] ANTIBIOTIC CONJUGATES<br/>[FR] CONJUGUÉS ANTIBIOTIQUES
  申请人：UNIV MONASH

  公开号：WO2021195716A1

  公开（公告）日：2021-10-07

  The present invention relates to conjugates comprising a glycopeptide antibiotic agent and a chemotactic formylated peptide and their use in the treatment or prevention of bacterial infections. The invention also relates to use of the conjugates in the prevention or treatment of bacterial infections.

  本发明涉及由糖肽抗生素药物和趋化性甲酰化肽形成的共轭物以及它们在治疗或预防细菌感染中的应用。本发明还涉及在预防或治疗细菌感染中使用这些共轭物。
• PSMA-TARGETED NIR DYES AND THEIR USES
  申请人：On Target Laboratories, LLC

  公开号：US20170066719A1

  公开（公告）日：2017-03-09

  The present disclosure relates to prostate specific membrane antigen (PSMA) targeted compounds conjugated to near-infra red (NIR) dyes and methods for their therapeutic and diagnostic use. More specifically, this disclosure provides compounds and methods for diagnosing and treating diseases associated with cells and/or vasculature expressing prostate specific membrane antigen (PSMA), such as prostate cancer and related diseases. The disclosure further describes methods and compositions for making and using the compounds, methods incorporating the compounds, and kits incorporating the compounds.

  本公开涉及针对前列腺特异性膜抗原（PSMA）的靶向化合物，这些化合物与近红外（NIR）染料结合，并且涉及其治疗和诊断用途的方法。更具体地说，本公开提供了用于诊断和治疗与表达前列腺特异性膜抗原（PSMA）的细胞和/或血管相关的疾病，如前列腺癌和相关疾病的化合物和方法。本公开进一步描述了制备和使用这些化合物的方法和组成物，包括将这些化合物纳入方法中和将这些化合物纳入试剂盒中的方法。
• Method for activating microbial rennet and further production of cheese
  申请人：GENENTECH, INC.

  公开号：EP0114507A1

  公开（公告）日：1984-08-01

  The production of microbial rennet by recombinant DNA techniques, and its use in cheesemaking. The microbial rennet produced in refractile form is reactivated by subjecting it to strongly denaturing conditions and sulfitolysis to break the disulfide bonds and introduce sulfonate groups: the sulfonated protein is then subjected to weakly denaturing conditions to refold it, and the disulfide bonds are recreated.

  利用 DNA 重组技术生产微生物凝乳酶，并将其用于奶酪制作。将以折射形式生产的微生物凝乳酶置于强变性条件下重新激活，并进行亚硫分解以断开二硫键并引入磺酸基团：然后将磺化蛋白质置于弱变性条件下重新折叠，再重新生成二硫键。
• Microbially produced rennet, methods for its production and plasmids used for its production
  申请人：GENENTECH, INC.

  公开号：EP0116778A1

  公开（公告）日：1984-08-29

  The production of microbial rennet by recombinant DNA techniques is disclosed; also plasmid expression vectors for transfecting a microbial host for efficient expression of e.g. prorennin, rennin and preprorennin.

  公开了利用 DNA 重组技术生产微生物凝乳酶；还公开了用于转染微生物宿主的质粒表达载体，以有效表达原肾素、肾素和前肾素等。