H-Thr-Arg-Ile-Asp-Glu-Ala-Asn-Gln-OH

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: H-Thr-Arg-Ile-Asp-Glu-Ala-Asn-Gln-OH
• 英文别名: (2S)-5-amino-2-[[(2S)-4-amino-2-[[(2S)-2-[[(2S)-2-[[(2S)-2-[[(2S,3S)-2-[[(2S)-2-[[(2S,3R)-2-amino-3-hydroxybutanoyl]amino]-5-(diaminomethylideneamino)pentanoyl]amino]-3-methylpentanoyl]amino]-3-carboxypropanoyl]amino]-4-carboxybutanoyl]amino]propanoyl]amino]-4-oxobutanoyl]amino]-5-oxopentanoic acid
• 化学式: C₃₇H₆₃N₁₃O₁₆
• 分子量: 946.0
• InChiKey: JINJRUBEFOFONO-IVWDKQLZSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -9.3
• 重原子数：
  66
• 可旋转键数：
  32
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.65
• 拓扑面积：
  512
• 氢给体数：
  16
• 氢受体数：
  18

文献信息

• LINKED PEPTIDE FLUOROGENIC BIOSENSORS
  申请人：Carnegie Mellon University

  公开号：EP2972355A1

  公开（公告）日：2016-01-20
• Linked Peptide Fluorogenic Biosensors
  申请人：CARNEGIE MELLON UNIVERSITY

  公开号：US20180095076A1

  公开（公告）日：2018-04-05

  Biosensors, compositions comprising biosensors, methods of producing biosensors, and methods of using biosensors are disclosed. The biosensors comprise a fluorogen-activating peptide and a blocking peptide. The blocking peptide associates with the fluorogen-activating peptide thereby blocking an active domain of the fluorogen-activating peptide. The fluorogen-activating peptide and blocking peptide are covalently linked in certain embodiments through a peptide linker. The peptide linker may contain an amino acid sequence that is specifically recognized as a modification substrate by a cognate enzyme. The fluorogen-activating peptide and the blocking peptide at least partially disassociate when the linker is modified by a cognate enzyme, thereby allowing the fluorogen-activating peptide to bind a cognate fluorogen and modulate a fluorescence signal.
• [EN] LINKED PEPTIDE FLUOROGENIC BIOSENSORS<br/>[FR] BIOCAPTEURS FLUOROGÉNIQUES À PEPTIDES LIÉS
  申请人：UNIV CARNEGIE MELLON

  公开号：WO2014142955A1

  公开（公告）日：2014-09-18

  Biosensors, compositions comprising biosensors, methods of producing biosensors, and methods of using biosensors are disclosed. The biosensors comprise a fluorogen- activating peptide and a blocking peptide. The blocking peptide associates with the fluorogen-activating peptide thereby blocking an active domain of the fluorogen-activating peptide. The fluorogen-activating peptide and blocking peptide are covalently linked in certain embodiments through a peptide linker. The peptide linker may contain an amino acid sequence that is specifically recognized as a modification substrate by a cognate enzyme. The fluorogen-activating peptide and the blocking peptide at least partially disassociate when the linker is modified by a cognate enzyme, thereby allowing the fluorogen-activating peptide to bind a cognate fluorogen and modulate a fluorescence signal.