hexadecanoic acid;[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-6-yl]methyl sulfamate

• 分子结构分类: 有机化合物 - 脂质和类脂质分子 - 脂肪酰基
• 英文名称: hexadecanoic acid;[(1R,2S,6S,9R)-4,4,11,11-tetramethyl-3,5,7,10,12-pentaoxatricyclo[7.3.0.02,6]dodecan-6-yl]methyl sulfamate
• 化学式: C28H53NO10S
• 分子量: 595.8
• InChiKey: KHIQNJLVMRZDDJ-VVBICHBISA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.16
• 重原子数：
  40
• 可旋转键数：
  17
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.96
• 拓扑面积：
  161
• 氢给体数：
  2
• 氢受体数：
  11

文献信息

• Rapidly dispersible dosage form of topiramate
  申请人：APRECIA PHARMACEUTICALS LLC

  公开号：US10420785B2

  公开（公告）日：2019-09-24

  A taste-masked rapidly dispersible dosage form of topiramate is provided. Wax coated particles of topiramate are included within a porous bound matrix. The topiramate retains its taste-masked form after dispersion in the mouth of a subject even though the particles are not coated with a polymeric material. The dosage form disperses in saliva or water in less than 2 min even though it has a high content of wax. It can be used to treat diseases or disorders that are therapeutically responsive to topiramate or a derivative thereof.

  本发明提供了一种托吡酯的掩味快速分散剂型。在多孔结合基质中含有蜡涂层的托吡酯颗粒。即使颗粒上没有涂覆聚合材料，托吡酯在受试者口中分散后仍能保持其掩味形式。即使蜡含量较高，该剂型在唾液或水中的分散时间也不超过 2 分钟。它可用于治疗对托吡酯或其衍生物有治疗反应的疾病或紊乱。
• RAPIDLY DISPERSIBLE DOSAGE FORM OF TOPIRAMATE
  申请人：Aprecia Pharmaceuticals LLC

  公开号：EP2968181B1

  公开（公告）日：2019-10-16
• Rapidly Dispersible Dosage Form of Topiramate
  申请人：APRECIA PHARMACEUTICALS COMPANY

  公开号：US20150366801A1

  公开（公告）日：2015-12-24

  A taste-masked rapidly dispersible dosage form of topiramate is provided. Wax coated particles of topiramate are included within a porous bound matrix. The topiramate retains its taste-masked form after dispersion in the mouth of a subject even though the particles are not coated with a polymeric material. The dosage form disperses in saliva or water in less than 2 min even though it has a high content of wax. It can be used to treat diseases or disorders that are therapeutically responsive to topiramate or a derivative thereof.
• US9492380B2
  申请人：——

  公开号：US9492380B2

  公开（公告）日：2016-11-15
• [EN] RAPIDLY DISPERSIBLE DOSAGE FORM OF TOPIRAMATE<br/>[FR] FORME POSOLOGIQUE À DISPERSION RAPIDE DE TOPIRAMATE
  申请人：APRECIA PHARMACEUTICALS COMPNY

  公开号：WO2014144661A1

  公开（公告）日：2014-09-18

  A taste-masked rapidly dispersible dosage form of topiramate is provided. Wax coated particles of topiramate are included within a porous bound matrix. The topiramate retains its taste-masked form after dispersion in the mouth of a subject even though the particles are not coated with a polymeric material. The dosage form disperses in saliva or water in less than 2 min even though it has a high content of wax. It can be used to treat diseases or disorders that are therapeutically responsive to topiramate or a derivative thereof.