(2-aminoacetyl) 2-aminoacetate;(2S)-2-amino-3-[(2R)-2-amino-3-sulfanylpropanoyl]oxypropanoic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (2-aminoacetyl) 2-aminoacetate;(2S)-2-amino-3-[(2R)-2-amino-3-sulfanylpropanoyl]oxypropanoic acid
• 化学式: C10H20N4O7S
• 分子量: 340.36
• InChiKey: ZKZZMTHDJLKBTE-MMALYQPHSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -3.83
• 重原子数：
  22
• 可旋转键数：
  10
• 环数：
  0.0
• sp3杂化的碳原子比例：
  0.6
• 拓扑面积：
  212
• 氢给体数：
  6
• 氢受体数：
  12

文献信息

• Collagen binding synthetic peptidoglycans for treatment of endothelial dysfunction
  申请人：Purdue Research Foundation

  公开号：US10772931B2

  公开（公告）日：2020-09-15

  Compositions and methods are provided for treating a patient suffering from a disease associated with endothelial dysfunction by administering to the patient a pharmaceutical composition containing an effective amount of a synthetic collagen binding peptidoglycan.

  本发明提供了治疗患有内皮功能障碍相关疾病的患者的组合物和方法，方法是向患者施用含有有效量合成胶原结合肽聚糖的药物组合物。
• EXTRACELLULAR MATRIX-BINDING SYNTHETIC PEPTIDOGLYCANS
  申请人：Purdue Research Foundation

  公开号：EP2970509B1

  公开（公告）日：2020-05-13
• COLLAGEN BINDING SYNTHETIC PEPTIDOGLYCANS FOR TREATMENT OF ENDOTHELIAL DYSFUNCTION
  申请人：Purdue Research Foundation

  公开号：US20170043023A1

  公开（公告）日：2017-02-16

  Compositions and methods are provided for treating a patient suffering from a disease associated with endothelial dysfunction by administering to the patient a pharmaceutical composition containing an effective amount of a synthetic collagen binding peptidoglycan.
• VE-CADHERIN BINDING BIOCONJUGATE
  申请人：Symic IP, LLC

  公开号：US20170112941A1

  公开（公告）日：2017-04-27

  This disclosure provides bioconjugate comprising a glycan and at least one peptide comprising a VE-Cadherin binding unit conjugated thereto, compositions comprising the same, and methods of use thereof.
• LUMINAL VESSEL COATING FOR ARTERIOVENOUS FISTULA
  申请人：Symic IP, LLC

  公开号：US20170368192A1

  公开（公告）日：2017-12-28

  This disclosure provides a method for improving maturation of an arteriovenous fistula (AVF) in a patient in need of hemodialysis, which method entails applying a solution to the internal wall of a lumen of an AVF; and restoring or initiating blood flow in the AVF, wherein the solution comprises an effective amount of a synthetic proteoglycan comprises a glycan having from about 1 to about 80 collagen-binding peptide(s) bonded to the glycan. Also provided are methods for preparing a vascular graft for a bypass surgery, comprising contacting the internal wall of a section of a blood vessel with a solution comprising an effective amount of the synthetic proteoglycan.