申请人:Consejo Nacional de Investigaciones Cientificas y Tecnicas (CONICET)
公开号:US10119145B2
公开(公告)日:2018-11-06
The present disclosure provides engineered microorganisms, engineered biosynthetic pathways, methods of producing lipid compounds using genetically engineered microorganisms, and the products synthesized by those organisms. In particular, the disclosure provides genetically engineered microorganisms for the production of multi-methyl branched fatty acids (MMBFAs) and MMBFA esters (wax esters) derived from these fatty acids. In addition, the disclosure provides methods for producing acylglycerols with one of more of their acyl substituents being an MMBFA, and methods for producing alcohols derived from MMBFAs (fatty alcohols).
本公开提供了工程微生物、工程生物合成途径、使用基因工程微生物生产脂类化合物的方法以及这些生物合成的产品。特别是,本公开提供了用于生产多甲基支链脂肪酸(MMBFA)和由这些脂肪酸衍生的多甲基支链脂肪酸酯(蜡酯)的基因工程微生物。此外,本公开还提供了生产酰基甘油(其酰基的一个或多个取代基为 MMBFA)的方法,以及生产由 MMBFA 衍生的醇(脂肪醇)的方法。