N-[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]-4-methoxynaphthalene-2-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: N-[(2S)-2-[[(2S)-2-[[(2S)-2-aminopropanoyl]amino]propanoyl]amino]-3-phenylpropanoyl]-4-methoxynaphthalene-2-carboxamide
• 化学式: C₂₇H₃₀N₄O₅
• 分子量: 490.5
• InChiKey: CZTSRHLENKHBNL-HOIFWPIMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  2.8
• 重原子数：
  36
• 可旋转键数：
  9
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.26
• 拓扑面积：
  140
• 氢给体数：
  4
• 氢受体数：
  6

文献信息

• METHODS FOR IDENTIFYING NEUROPROTECTIVE PKC ACTIVATORS
  申请人：Blanchette Rockefeller Neurosciences Institute

  公开号：EP3010500A1

  公开（公告）日：2016-04-27
• [EN] METHODS FOR IDENTIFYING NEUROPROTECTIVE PKC ACTIVATORS<br/>[FR] MÉTHODES D'IDENTIFICATION D'ACTIVATEURS PKC NEUROPROTECTEURS
  申请人：ALKON DANIEL L

  公开号：WO2014145316A1

  公开（公告）日：2014-09-18

  The present disclosure is directed to methods of identifying neuroprotective PKC activators comprising analyzing candidate PKC activators to determine if they are non-tumorigenic, non-toxic, accessible to the brain, have α and ε specificity, result in minimal down regulation of the ε isozyme, are synapatogenic, and are anti-apoptotic. The methods disclosed herein may further comprise analyzing candidate PKC activators to determine whether they are neuroprotective against ASPD, protect against in vivo neurodegeneration, enhance learning and memory in normal animal modesl, induce downstream synaptogenic biochemical events, activate Α-β degrading enzymes, inhibit GSK-3β, and/or activate alpha-secretase.