(7S,12S,17S,20S,23S,26S,29R)-29-[2-(diethylamino)ethylsulfanylmethyl]-26-(2-hydroxy-2-methylpropyl)-1,5,8,10,13,17,21,27-octamethyl-12,20-bis(2-methylpropyl)-7,23-di(propan-2-yl)-1,3,5,8,10,13,15,18,21,24,27-undecazacyclononacosane-2,4,6,9,11,14,16,19,22,25,28-undecone

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: (7S,12S,17S,20S,23S,26S,29R)-29-[2-(diethylamino)ethylsulfanylmethyl]-26-(2-hydroxy-2-methylpropyl)-1,5,8,10,13,17,21,27-octamethyl-12,20-bis(2-methylpropyl)-7,23-di(propan-2-yl)-1,3,5,8,10,13,15,18,21,24,27-undecazacyclononacosane-2,4,6,9,11,14,16,19,22,25,28-undecone
• 化学式: C₅₁H₉₂N₁₂O₁₂S
• 分子量: 1097.4
• InChiKey: DDFRSVPAJDGWAZ-ZTYVOHGWSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.5
• 重原子数：
  76
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  307
• 氢给体数：
  5
• 氢受体数：
  14

文献信息

• [EN] NOVEL CYCLOSPORIN DERIVATIVES AND USES THEREOF<br/>[FR] NOUVEAUX DÉRIVÉS DE CYCLOSPORINE ET LEURS UTILISATIONS
  申请人：SU ZHUANG

  公开号：WO2014145686A2

  公开（公告）日：2014-09-18

  The present invention relates to a compound of the Formula (I)): or pharmaceutically acceptable salt thereof, wherein the symbols are as defined in the specification; a pharmaceutical composition comprising the same, a method for treating or preventing viral infections, inflammation, dry eye, central nervous disorders, cardiovascular diseases, cancer, obesity, diabetes, muscular dystrophy, and hair loss.