This invention relates to 2-Aza-bicyclo[2.2.1]heptane-3-carboxylic acid (benzyl-cyano-methyl)-amides of formula 1
and their use as inhibitors of Cathepsin C, pharmaceutical compositions containing the same, and methods of using the same as agents for treatment and/or prevention of diseases connected with dipeptidyl peptidase I activity, e.g. respiratory diseases.
本发明涉及式 1 的
2-氮杂双环[2.2.1]庚烷-3-
羧酸(苄基-
氰基-甲基)酰胺
及其作为 Cathepsin C
抑制剂的用途、含有这些物质的药物组合物,以及将这些物质用作治疗和/或预防与二肽基肽酶 I 活性有关的疾病(如呼吸系统疾病)的药物的方法。