2-[4-(Carboxymethyl)-10-(2-oxoethyl)-7-(1-oxotetradecan-2-yl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 2-[4-(Carboxymethyl)-10-(2-oxoethyl)-7-(1-oxotetradecan-2-yl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
• 英文别名: 2-[4-(carboxymethyl)-10-(2-oxoethyl)-7-(1-oxotetradecan-2-yl)-1,4,7,10-tetrazacyclododec-1-yl]acetic acid
• 化学式: C₂₈H₅₂N₄O₆
• 分子量: 540.7
• InChiKey: UQYBZGLMSIVBOO-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  0
• 重原子数：
  38
• 可旋转键数：
  19
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.86
• 拓扑面积：
  122
• 氢给体数：
  2
• 氢受体数：
  10

文献信息

• PARTICLES COMPRISING LUMINESCENT LANTHANIDE COMPLEXES
  申请人：CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE (C.N.R.S.)

  公开号：US20160030599A1

  公开（公告）日：2016-02-04

  The present invention relates to particles, useful for drug release detection, comprising: at least one luminescent metal complex of formula [Ln].[L], wherein: Ln is a lanthanide ion, L is an organic ligand comprising a hydrophilic unit with at least 6 chelating groups chosen from the group consisting of hydroxyl, carboxyl, optionally in the carboxylate form, carbonyl, ether, phosphonate, phosphinate, thiolate, amino and imino functions, and at least one drug comprising a conjugated aromatic system, wherein said drug is not covalently bonded to the metal complex, said particle having a size comprised from 3 nm to 2000 nm, and wherein the distribution of the metal complex and the drug within the particle is such that the mean distance between a drug molecule and a metal complex is less than 15 nm.
• [EN] PARTICLES COMPRISING LUMINESCENT LANTHANIDE COMPLEXES<br/>[FR] PARTICULES COMPRENANT DES COMPLEXES LUMINESCENTS DE LANTHANIDES
  申请人：CENTRE NAT RECH SCIENT

  公开号：WO2014140203A1

  公开（公告）日：2014-09-18

  The present invention relates to particles, useful for drug release detection, comprising: at least one luminescent metal complex of formula [Ln].[L], wherein: Ln is a lanthanide ion, L is an organic ligand comprising a hydrophilic unit with at least 6 chelating groups chosen from the group consisting of hydroxyl, carboxyl, optionally in the carboxylate form, carbonyl, ether, phosphonate, phosphinate, thiolate, amino and imino functions, and - at least one drug comprising a conjugated aromatic system, wherein said drug is not covalently bonded to the metal complex, said particle having a size comprised from 3 nm to 2 000 nm, and wherein the distribution of the metal complex and the drug within the particle is such that the mean distance between a drug molecule and a metal complex is less than 15 nm.