(6aS)-3-[5-[[(6aS)-2-methoxy-8-[4-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]phenyl]-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]pentoxy]-8-(4-aminophenyl)-2-methoxy-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one

• 分子结构分类: 有机化合物 - 有机杂环化合物 - 吡咯啉
• 英文名称: (6aS)-3-[5-[[(6aS)-2-methoxy-8-[4-[2-[2-[2-(2-methoxyethoxy)ethoxy]ethoxy]ethoxy]phenyl]-11-oxo-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-3-yl]oxy]pentoxy]-8-(4-aminophenyl)-2-methoxy-6a,7-dihydropyrrolo[2,1-c][1,4]benzodiazepin-11-one
• 化学式: C₅₂H₅₉N₅O₁₁
• 分子量: 930.0
• InChiKey: AHEAWAGKBFYQSV-YATWDLPUSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  4
• 重原子数：
  68
• 可旋转键数：
  25
• 环数：
  8.0
• sp3杂化的碳原子比例：
  0.38
• 拓扑面积：
  174
• 氢给体数：
  1
• 氢受体数：
  14

文献信息

• ACTIVATED CARBON FILTRATION FOR PURIFICATION OF BENZODIAZEPINE ADCS
  申请人：Seattle Genetics, Inc.

  公开号：EP3441072A1

  公开（公告）日：2019-02-13

  Disclosed are methods of purifying mixtures comprising benzodiazepine antibody-drug conjugates.

  所公开的是纯化包含苯并二氮杂卓抗体-药物共轭物的混合物的方法。
• Cyclodextrin and antibody-drug conjugate formulations
  申请人：SEATTLE GENETICS, INC.

  公开号：US10391181B2

  公开（公告）日：2019-08-27

  Disclosed are formulations, including both liquid and lyophilized formulations, comprising a benzodiazepine antibody-drug conjugate (ADC) and a cyclodextrin. Also disclosed are methods of purifying mixtures comprising benzodiazepine antibody-drug conjugates and process drug-related impurities.

  所公开的制剂包括液体制剂和冻干制剂，其中包含苯并二氮杂卓抗体-药物共轭物（ADC）和环糊精。还公开了纯化包含苯二氮卓抗体-药物共轭物和加工药物相关杂质的混合物的方法。
• CYCLODEXTRIN AND ANTIBODY-DRUG CONJUGATE FORMULATIONS
  申请人：SEATTLE GENETICS, INC.

  公开号：US20170232112A1

  公开（公告）日：2017-08-17

  Disclosed are formulations, including both liquid and lyophilized formulations, comprising a benzodiazepine antibody-drug conjugate (ADC) and a cyclodextrin. Also disclosed are methods of purifying mixtures comprising benzodiazepine antibody-drug conjugates and process drug-related impurities.
• US9453046B2
  申请人：——

  公开号：US9453046B2

  公开（公告）日：2016-09-27
• US9610361B2
  申请人：——

  公开号：US9610361B2

  公开（公告）日：2017-04-04