methyl 4-[[(3aR,6aR)-4-(6-amino-4,5-dihydropurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methylamino]butanoate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: methyl 4-[[(3aR,6aR)-4-(6-amino-4,5-dihydropurin-9-yl)-2,2-dimethyl-3a,4,6,6a-tetrahydrofuro[3,4-d][1,3]dioxol-6-yl]methylamino]butanoate
• 化学式: C₁₈H₂₈N₆O₅
• 分子量: 408.5
• InChiKey: ZMUNDRLXGFCHTG-RPVFIULJSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -1.8
• 重原子数：
  29
• 可旋转键数：
  8
• 环数：
  4.0
• sp3杂化的碳原子比例：
  0.78
• 拓扑面积：
  132
• 氢给体数：
  2
• 氢受体数：
  8

文献信息

• [EN] IMMUNOASSAY OF S-ADENOSYLMETHIONINE USING ANALOGS THEREOF AND PERSONALIZED THERAPEUTICS<br/>[FR] IMMUNOESSAI DE LA S-ADÉNOSYLMÉTHIONINE FAISANT APPEL À DES ANALOGUES DE CETTE DERNIÈRE ET THÉRAPEUTIQUE PERSONNALISÉE
  申请人：HUNAN SKYWORLD BIOTECHNOLOGIES CO

  公开号：WO2014146137A1

  公开（公告）日：2014-09-18

  A method of detecting the presence or absence of a disease in a patient wherein said disease is accompanied by deficient levels of S-adenosylmethionine comprising: identifying a patient that is suspected of having said disease or is at risk of having said disease; obtaining a biological sample from said patient; determining the level of S-adenosylmethionine in said biological sample using an antibody derived from a hapten analog of S-adenosylmethionine; and correlating the level of S-adenosylmethionine in said biological sample with the presence or absence of said disease. The invention also provides methods for meauring SAH which is used to determine the methylation index (ratio of SAM/SAH) in biological fluids which is indicative ofm the health status of an individual.

  一种检测患者是否患有伴随着S-腺苷甲硫氨酸缺乏的疾病的方法，包括：识别疑似患有该疾病或有患病风险的患者；从该患者获取生物样本；使用源自S-腺苷甲硫氨酸类似物的半抗原抗体测定所述生物样本中S-腺苷甲硫氨酸的水平；并将所述生物样本中S-腺苷甲硫氨酸的水平与所述疾病的存在或不存在相关联。该发明还提供了测量SAH的方法，该方法用于确定生物液体中的甲基化指数（SAM / SAH比率），该指数表明个体的健康状况。
• US9885723B2
  申请人：——

  公开号：US9885723B2

  公开（公告）日：2018-02-06