3-O-(2,5-dioxopyrrolidin-1-yl) 1-O-[2-(2-ethoxyethoxy)ethyl] propanedioate

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-O-(2,5-dioxopyrrolidin-1-yl) 1-O-[2-(2-ethoxyethoxy)ethyl] propanedioate
• 化学式: C₁₃H₁₉NO₈
• 分子量: 317.29
• InChiKey: KTFNBCHLCMUVFY-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  -0.7
• 重原子数：
  22
• 可旋转键数：
  12
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.69
• 拓扑面积：
  108
• 氢给体数：
  0
• 氢受体数：
  8

文献信息

• US20140271528A1
  申请人：——

  公开号：US20140271528A1

  公开（公告）日：2014-09-18
• SOLID POLYGLYCOL-BASED BIOCOMPATIBLE PRE-FORMULATION
  申请人：Medicus Biosciences LLC

  公开号：US20150190544A1

  公开（公告）日：2015-07-09

  Provided herein are pre-formulations forming a biocompatible hydrogel polymer comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the biocompatible hydrogel polymer covers a wound in a mammal and adheres to the surrounding skin tissue. In other embodiments, the hydrogel polymer is delivered into a joint space to treat joint disease or navicular disease.
• BIOCOMPATIBLE HYDROGEL TREATMENTS FOR RETINAL DETACHMENT
  申请人：Medicus Biosciences LLC

  公开号：US20150273108A1

  公开（公告）日：2015-10-01

  Provided herein are in vivo gelling ophthalmic pre-formulations forming a biocompatible retinal patch comprising at least one nucleophilic compound or monomer unit, at least one electrophilic compound or monomer unit, and optionally a therapeutic agent and/or viscosity enhancer. In some embodiments, the retinal patch at least partially adheres to the site of a retinal tear. Also provided herein are methods of treating retinal detachment by delivering an in vivo gelling ophthalmic pre-formulation to the site of a retinal tear in human eye, wherein the in vivo gelling ophthalmic pre-formulation forms a retinal patch.
• BIOCOMPATIBLE HYDROGEL POLYMER MATRIX FOR DELIVERY OF CELLS
  申请人：Medicus Biosciences LLC

  公开号：US20180050129A1

  公开（公告）日：2018-02-22

  Provided herein are biocompatible hydrogel polymer matrices, which are prepared from biocompatible pre-formulations. The biocompatible pre-formulations comprise at least one nucleophilic compound, at least one electrophilic compound, and at least one cell. The biocompatible hydrogel polymer matrix is bioabsorbable and releases the cell at a target site, achieving a controlled delivery. The biocompatible hydrogel polymer matrix provides a solid support conducive for cell viability and functionality. The cells may grow on the hydrogel polymer surface of inside the hydrogel polymer matrix.
• US8987339B2
  申请人：——

  公开号：US8987339B2

  公开（公告）日：2015-03-24