3-[[(2R)-4,4-dimethyl-3-oxo-1-sulfanylpentan-2-yl]amino]sulfanyl-1-[[4-(2,2-dimethylpropanoyl)cyclohexyl]methyl]pyrrolidine-2,5-dione

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 3-[[(2R)-4,4-dimethyl-3-oxo-1-sulfanylpentan-2-yl]amino]sulfanyl-1-[[4-(2,2-dimethylpropanoyl)cyclohexyl]methyl]pyrrolidine-2,5-dione
• 化学式: C₂₃H₃₈N₂O₄S₂
• 分子量: 470.7
• InChiKey: JKWSFGNXRJYLAW-PYCMUAIMSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  3.9
• 重原子数：
  31
• 可旋转键数：
  10
• 环数：
  2.0
• sp3杂化的碳原子比例：
  0.83
• 拓扑面积：
  110
• 氢给体数：
  2
• 氢受体数：
  7

文献信息

• US20140271650A1
  申请人：——

  公开号：US20140271650A1

  公开（公告）日：2014-09-18
• IMMUNOGENIC PEPTIDE CONJUGATE AND METHOD FOR INDUCING AN ANTI-INFLUENZA THERAPEUTIC ANTIBODY RESPONSE THEREWITH
  申请人：THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

  公开号：US20170258902A1

  公开（公告）日：2017-09-14

  Immunogenic influenza hemagglutinin-derived peptide conjugates described herein induce a specific therapeutic antibody response against influenza virus. The immunogenic peptide conjugates comprise a segment from the fusion initiation region (FIR) domain of an influenza hemagglutinin protein conjugated to an immunogenic carrier protein, such asbovine serum albumin (BSA), an influenza hemagglutinin (HA) protein (i.e., full length HA), and the like. The immunogenic peptide conjugates described herein can be utilized to treat or prevent influenza infection and to prepare influenza-specific therapeutic antibodies that interfere with influenza virus-host cell membrane fusion. The peptide conjugates can be formulated in pharmaceutical compositions useful for broad spectrum treatment or prevention of influenza infections.
• IMMUNOGENIC PEPTIDE COMPOSITION AND METHOD
  申请人：THE ADMINISTRATORS OF THE TULANE EDUCATIONAL FUND

  公开号：US20190054168A1

  公开（公告）日：2019-02-21

  Immunogenic influenza hemagglutinin-derived peptide compositions described herein induce a specific therapeutic antibody response against influenza virus. The immunogenic peptide compositions comprise a segment from the fusion initiation region (FIR) domain of an influenza hemagglutinin protein bound to an immunogenic carrier protein, such as an influenza hemagglutinin (HA) protein (i.e., full length HA), and the like. The immunogenic peptide compositions described herein can be utilized to treat or prevent influenza infection and to prepare influenza-specific therapeutic antibodies that interfere with influenza virus-host cell membrane fusion. The peptide conjugates can be formulated in pharmaceutical compositions useful for broad spectrum treatment or prevention of influenza infections
• US9649375B2
  申请人：——

  公开号：US9649375B2

  公开（公告）日：2017-05-16