4-[(8S)-8-amino-9-methyl-6,7-dioxodecyl]-N-(5-aminopentyl)-1,3-thiazolidine-2-carboxamide

• 分子结构分类: 有机化合物 - 有机酸及其衍生物 - 羧酸及其衍生物
• 英文名称: 4-[(8S)-8-amino-9-methyl-6,7-dioxodecyl]-N-(5-aminopentyl)-1,3-thiazolidine-2-carboxamide
• 化学式: C₂₀H₃₈N₄O₃S
• 分子量: 414.6
• InChiKey: GOEKDOXJCPDYJW-CMVHYPBASA-N

计算性质

• 辛醇/水分配系数(LogP)：
  1.3
• 重原子数：
  28
• 可旋转键数：
  15
• 环数：
  1.0
• sp3杂化的碳原子比例：
  0.85
• 拓扑面积：
  153
• 氢给体数：
  4
• 氢受体数：
  7

文献信息

• [EN] ENZYMATIC CONJUGATION OF POLYPEPTIDES<br/>[FR] CONJUGAISON ENZYMATIQUE DE POLYPEPTIDES
  申请人：INNATE PHARMA

  公开号：WO2014202775A1

  公开（公告）日：2014-12-24

  The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.

  本申请涉及一种用于酶催化免疫球蛋白功能化的方法，特别是与药物结合的方法。本文还披露了连接试剂、功能化抗体、药物组合物以及治疗疾病和/或症状的方法。
• [EN] SOLID PHASE TGASE-MEDIATED CONJUGATION OF ANTIBODIES<br/>[FR] CONJUGAISON D'ANTICORPS EN PHASE SOLIDE MÉDIÉE PAR LA TGASE
  申请人：INNATE PHARMA

  公开号：WO2014140300A1

  公开（公告）日：2014-09-18

  The present invention relates to solid-support based processess for the functionalization of immunoglobulins through the use of transglutaminase. Also provided are solid support compositions with bound antibody. The methods can be used, for example, in manufacturing processes or in drug screening.

  本发明涉及基于固体支持的免疫球蛋白功能化过程，通过使用转谷氨酰胺酶完成。同时提供了固体支持物质，其中包含结合抗体。该方法可以用于制造过程或药物筛选等方面。
• ENZYMATIC CONJUGATION OF ANTIBODIES
  申请人：Innate Pharma

  公开号：US20140356385A1

  公开（公告）日：2014-12-04

  The present application relates to methods for the functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
• ENZYMATIC CONJUGATION OF POLYPEPTIDES
  申请人：Innate Pharma

  公开号：US20150165064A1

  公开（公告）日：2015-06-18

  The present application relates to methods for the enzymatic functionalization of immunoglobulins, in particular with drugs. Also disclosed herein are linking reagents, functionalized antibodies, pharmaceutical compositions, and method of treating disease and/or conditions.
• US9427478B2
  申请人：——

  公开号：US9427478B2

  公开（公告）日：2016-08-30