2-(4-chloro-2-methoxyphenoxy)-N-[4-[2-(4-chloro-2-methoxyphenoxy)propanoylamino]cyclohexyl]propanamide

• 分子结构分类: 有机化合物 - 苯类化合物 - 苯酚醚
• 英文名称: 2-(4-chloro-2-methoxyphenoxy)-N-[4-[2-(4-chloro-2-methoxyphenoxy)propanoylamino]cyclohexyl]propanamide
• 化学式: C₂₆H₃₂Cl₂N₂O₆
• 分子量: 539.4
• InChiKey: NHYJJQYRLYBMJN-UHFFFAOYSA-N

计算性质

• 辛醇/水分配系数(LogP)：
  5.6
• 重原子数：
  36
• 可旋转键数：
  10
• 环数：
  3.0
• sp3杂化的碳原子比例：
  0.46
• 拓扑面积：
  95.1
• 氢给体数：
  2
• 氢受体数：
  6

文献信息

• Modulators of the eIF2alpha pathway
  申请人：The Regents of the University of California

  公开号：US10343981B2

  公开（公告）日：2019-07-09

  Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2α phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.

  本文提供的化合物和方法主要用于调节 eIF2α 磷酸化、综合应激反应（ISR）和未折叠蛋白反应（UPR）的翻译效应；治疗疾病；增加蛋白质产量以及改善长期记忆。
• MODULATORS OF THE EIF2ALPHA PATHWAY
  申请人：The Regents of the University of California

  公开号：US20160096800A1

  公开（公告）日：2016-04-07

  Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2α phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.
• US9708247B2
  申请人：——

  公开号：US9708247B2

  公开（公告）日：2017-07-18
• [EN] MODULATORS OF THE EIF2ALPHA PATHWAY<br/>[FR] MODULATEURS DE LA VOIE EIF2 ALPHA
  申请人：WALTER PETER

  公开号：WO2014144952A2

  公开（公告）日：2014-09-18

  Provided herein, inter alia, are compounds and methods useful for modulating the translational effects of eIF2 phosphorylation, the Integrated Stress Response (ISR), and the unfolded protein response (UPR); for treating diseases; for increasing protein production, and for improving long-term memory.